EREG and MS4A13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EREG	MS4A13
Description		epiregulin	membrane spanning 4-domains A13
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane	Plasma Membrane Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Protein Binding
	Biological Process	Angiogenesis Ovarian Cumulus Expansion Oocyte Maturation Positive Regulation Of Cytokine Production Female Meiotic Nuclear Division Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation MRNA Transcription Anatomical Structure Morphogenesis Animal Organ Morphogenesis Cytokine-mediated Signaling Pathway Cell Differentiation Keratinocyte Differentiation Ovulation Positive Regulation Of Interleukin-6 Production ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Wound Healing Positive Regulation Of Phosphorylation Luteinizing Hormone Signaling Pathway Response To Peptide Hormone Keratinocyte Proliferation Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of Fibroblast Proliferation Primary Follicle Stage Animal Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division	Cell Surface Receptor Signaling Pathway
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18821565) Breast size ( 22747683) Metabolite levels ( 22916037)	Congenital heart disease (maternal effect) ( 28468790) Major depressive disorder ( 29317602) Metabolite levels (X-11787) ( 23934736)
Interacting Genes		7 interacting genes: CFTR CXCL9 EGFR ERBB4 MS4A13 NINJ2 OLFM4	63 interacting genes: AQP2 AQP6 ASGR2 ATP6V0E1 BEST1 BIK CBARP CD79A CLDN7 CREB3L1 CREB3L3 DAGLA EBP EDA EREG ERGIC3 EVA1A FAM209A FAM210B FFAR2 GJA4 GJA5 GJA8 GJB1 GJB5 GJB6 GJC3 GPR152 GPR42 HERPUD2 JSRP1 KCNMB4 KLRC1 LHFPL5 LRRC3B MMGT1 MS4A3 NPDC1 ODF4 POMK RAMP1 RHCG RNF185 SCN3B SLC10A6 SLC12A7 SLC13A4 SLC16A2 SLC18A1 SLC30A2 SLC39A2 SLC7A1 SPAG4 SSMEM1 TBXA2R TLCD4 TM4SF18 TMC4 TMEM14B TMEM237 TMEM52B TMEM74 VSIR
Entrez ID		2069	503497
HPRD ID		03638	17604
Ensembl ID		ENSG00000124882	ENSG00000204979
Uniprot IDs		O14944	Q5J8X5
PDB IDs		1K36 1K37 5E8D 5WB7 7LEN 7LFR 7LFS 8HGP
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Activity ERBB2 Signaling Pathway Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Basolateral Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Protein Localization Cellular Response To Lipid Positive Regulation Of Anion Channel Activity Shc-EGFR Complex Central Nervous System Morphogenesis Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Protein Kinase C Signaling Protein Tyrosine Kinase Activity Neuregulin Receptor Activity Regeneration Positive Regulation Of Enamel Mineralization Epidermal Growth Factor Binding Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation Membrane Destabilizing Activity Plasma Membrane Transepithelial Water Transport Regulation Of Protein Kinase C Signaling ERBB2-ERBB4 Signaling Pathway CXCR3 Chemokine Receptor Binding Early Endosome Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Protein-containing Complex Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Positive Regulation Of ERK1 And ERK2 Cascade ERBB4-ERBB4 Signaling Pathway	Membrane Transmembrane Transport Connexin Complex Gap Junction Channel Activity Gap Junction Plasma Membrane Monoatomic Ion Transport Protein Binding Inorganic Ion Transmembrane Transport Gap Junction Assembly Cell-cell Signaling Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Signaling Cell Communication Metal Ion Transport Cell Communication By Electrical Coupling Inorganic Anion Transmembrane Transport Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell-cell Junction Assembly Anchoring Junction Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Inorganic Anion Transport SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport AV Node Cell To Bundle Of His Cell Communication Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Renal Water Transport Endoplasmic Reticulum Membrane Channel Activity Monoatomic Cation Transmembrane Transport Ammonium Channel Activity Chloride Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Transmembrane Transporter Activity Cell-cell Junction Organization Ammonium Transmembrane Transport Intercellular Transport Chloride Transport System Process Amine Transport Transport Vesicle Membrane Water Channel Activity Monoatomic Anion Transmembrane Transport Carbon Dioxide Transport Cell Communication By Electrical Coupling Involved In Cardiac Conduction
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