EREG

Gene Name		epiregulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Integral Component Of Plasma Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Activation Of MAPK Activity Angiogenesis Ovarian Cumulus Expansion Oocyte Maturation Positive Regulation Of Cytokine Production Female Meiotic Division Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway MRNA Transcription Anatomical Structure Morphogenesis Organ Morphogenesis Cytokine-mediated Signaling Pathway Keratinocyte Differentiation Ovulation Fc-epsilon Receptor Signaling Pathway Wound Healing Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Phosphorylation Luteinizing Hormone Signaling Pathway Response To Peptide Hormone Keratinocyte Proliferation Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Primary Follicle Stage Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18821565) Breast size ( 22747683) Metabolite levels ( 22916037)
Protein-protein Interactions		2 interactors: EGFR ERBB4
Entrez ID		2069
HPRD ID		03638
Ensembl ID		ENSG00000124882
Uniprot IDs		O14944
PDB IDs		1K36 1K37
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Import Into Nucleus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Regulation Of Protein Localization To Nucleus Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Telencephalon Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Central Nervous System Morphogenesis Astrocyte Activation Positive Regulation Of Protein Transport Positive Regulation Of STAT Protein Import Into Nucleus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Activation Of Phospholipase A2 Activity Regulation Of Intracellular Transport Forebrain Development Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase A2 Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Gland Development Regulation Of Cellular Ketone Metabolic Process Response To Cobalamin Response To UV-A Response To Hydroxyisoflavone Positive Regulation Of Transferase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation
Tagcloud ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo dusp4 epgn epigen epiregulin erbb3 erbb4 folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa