EREG and NINJ2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EREG	NINJ2
Description		epiregulin	ninjurin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane	Plasma Membrane Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Protein Binding Cholesterol Binding Membrane Destabilizing Activity
	Biological Process	Angiogenesis Ovarian Cumulus Expansion Oocyte Maturation Positive Regulation Of Cytokine Production Female Meiotic Nuclear Division Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation MRNA Transcription Anatomical Structure Morphogenesis Animal Organ Morphogenesis Cytokine-mediated Signaling Pathway Cell Differentiation Keratinocyte Differentiation Ovulation Positive Regulation Of Interleukin-6 Production ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Wound Healing Positive Regulation Of Phosphorylation Luteinizing Hormone Signaling Pathway Response To Peptide Hormone Keratinocyte Proliferation Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of Fibroblast Proliferation Primary Follicle Stage Animal Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division	Cell Adhesion Neuron Cell-cell Adhesion Nervous System Development Cytolysis Tissue Regeneration
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18821565) Breast size ( 22747683) Metabolite levels ( 22916037)	Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte count ( 27863252 32888494) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Rheumatic heart disease ( 34106200) Stroke ( 19369658) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CFTR CXCL9 EGFR ERBB4 MS4A13 NINJ2 OLFM4	79 interacting genes: AMIGO1 AQP6 ARL13B BCL2L13 BTNL9 CD69 CD79A CEACAM3 CHODL CLEC17A CLEC7A CPLX4 CREB3L1 CYBC1 EBP ELOVL4 ELOVL5 EREG ERGIC3 ERVFRD-1 EVI2B FAM209A FAM210B FCGRT FCRL4 FNDC9 GJA1 GJA8 GPR152 GPR42 GPX8 ICAM3 IFNGR1 IL3RA JAGN1 KCNJ6 KIR2DL3 KIR3DL3 LDLRAD1 LHFPL5 LMNA LYPD5 LYVE1 M6PR MGST3 MMGT1 MR1 MUC1 ODF4 PIGP PVR REEP4 RIC3 RNASEK SCN3B SLAMF8 SLC10A1 SLC10A6 SLC35H1 SLC66A1 SLC7A14 SLC7A8 SSMEM1 STX1A STX2 TM4SF20 TMEM101 TMEM139 TMEM14B TMEM31 TMEM51 TMEM52B TMEM86B TMEM9 TMPRSS2 TMX2 TSPAN12 VMA21 VSIG1
Entrez ID		2069	4815
HPRD ID		03638	09530
Ensembl ID		ENSG00000124882	ENSG00000171840
Uniprot IDs		O14944	A0A590UJR9 B4DJC1 F5H3L1 F8WBZ3 Q9NZG7
PDB IDs		1K36 1K37 5E8D 5WB7 7LEN 7LFR 7LFS 8HGP	8SZB
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Activity ERBB2 Signaling Pathway Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Basolateral Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Establishment Of Planar Polarity Involved In Nephron Morphogenesis Positive Regulation Of Protein Localization Cellular Response To Lipid Positive Regulation Of Anion Channel Activity Shc-EGFR Complex Central Nervous System Morphogenesis Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Protein Kinase C Signaling Protein Tyrosine Kinase Activity Neuregulin Receptor Activity Regeneration Positive Regulation Of Enamel Mineralization Epidermal Growth Factor Binding Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation Membrane Destabilizing Activity Plasma Membrane Transepithelial Water Transport Regulation Of Protein Kinase C Signaling ERBB2-ERBB4 Signaling Pathway CXCR3 Chemokine Receptor Binding Early Endosome Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Protein-containing Complex Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Positive Regulation Of ERK1 And ERK2 Cascade ERBB4-ERBB4 Signaling Pathway	Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Intracellular PH Reduction External Side Of Plasma Membrane Bile Acid:sodium Symporter Activity Lysosomal Lumen Acidification
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