RNF43

Gene Name		ring finger protein 43
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Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Stem Cell Proliferation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Pancreatic cancer ( 20686608)
Protein-protein Interactions		8 interactors: RSPO1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N
Entrez ID		54894
HPRD ID		07896
Ensembl ID		ENSG00000108375
Uniprot IDs		Q68DV7
PDB IDs		4KNG
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Innate Immune Response Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Macromolecule Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Protein Modification Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Immune Response Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Cellular Protein Metabolic Process Proteolysis Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Spindle Checkpoint Innate Immune Response Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Response To Hypoxia Regulation Of Immune Response
Tagcloud ?		adherens anoikis arid1a cdh1 clustered complexity ctnna2 driver escape gli3 guided highlights hotspots illustrate integrative junction landscape muc6 multidimensional mutational organoid personalized perturbations perturbed players rhoa road signatures top