EPHB1 and GRB10

Number of citations of the paper that reports this interaction (PMID 8798570)
22

Data Source:
HPRD (in vitro, two hybrid)

		EPHB1	GRB10
Gene Name		EPH receptor B1	growth factor receptor-bound protein 10
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Early Endosome Membrane Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity	SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding
	Biological Process	Angiogenesis Axon Guidance Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death	Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Insulin Negative Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Signaling by SCF-KIT Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events SHC activation Signaling by Insulin receptor
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Acute lymphoblastic leukemia (childhood) ( 23512250) Bone mineral density ( 22504420) Fasting glucose-related traits (interaction with BMI) ( 22581228) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		11 interactors: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 GRB10 GRB2 NCK1 PRKCG PXN	30 interactors: ABL1 AKT1 APP BCR DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET RQCD1 SRC ZDHHC17
Entrez ID		2047	2887
HPRD ID		02790	03312
Ensembl ID		ENSG00000154928	ENSG00000106070
Uniprot IDs		P54762	Q13322
PDB IDs		2DJS 2EAO	1NRV 3HK0
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Axon Guidance Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Morphogenesis Neuron Projection Morphogenesis Cell Projection Organization Neuron Projection Development Cell Surface Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Neuron Development Neuron Differentiation Cell Development Locomotion Nervous System Development Generation Of Neurons Anatomical Structure Morphogenesis Neurogenesis Signal Transduction Response To External Stimulus Regulation Of Cell Adhesion Signaling Cell Communication Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Signal Complex Assembly Multicellular Organismal Development Cell Differentiation Regulation Of Phosphorus Metabolic Process Cell Migration Cellular Response To Stimulus Anatomical Structure Development Cell Motility Cell-cell Signaling Positive Regulation Of Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Developmental Process System Development Positive Regulation Of T Cell Activation Cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Phosphorylation Cellular Response To Organic Substance Intracellular Signal Transduction Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration ERBB Signaling Pathway Positive Regulation Of Cell Motility Peptidyl-amino Acid Modification Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Component Movement Signal Transduction Positive Regulation Of Locomotion Regulation Of Signaling Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Signaling Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Communication Cellular Response To Peptide Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Response To Hormone Regulation Of Cell Migration Fibroblast Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Fc Receptor Signaling Pathway
Tagcloud ?		anlage b3 cascades cortical cue endogenously entering ephrin fak gives interneurons migrate migrating misrouted path pfak poa preoptic psrc repulsion repulsive reverse stop str striatal striatum superficial terminate	becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights interacting looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned
Tagcloud (Difference) ?		anlage b3 cascades cortical cue endogenously entering ephrin fak gives interneurons migrate migrating misrouted path pfak poa preoptic psrc repulsion repulsive reverse stop str striatal striatum superficial terminate	becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights interacting looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned
Tagcloud (Intersection) ?