EPHB1 and UQCRC2

		EPHB1	UQCRC2
Description		EPH receptor B1	ubiquinol-cytochrome c reductase core protein 2
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Axon Dendrite Early Endosome Membrane Filopodium Tip Cell Projection Membrane Raft Extracellular Exosome Glutamatergic Synapse	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Protein-containing Complex Binding	Metalloendopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Immunological Synapse Formation Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Skeletal Muscle Satellite Cell Activation Cell Migration Cranial Nerve Development Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis System Development Modulation Of Chemical Synaptic Transmission Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Proteolysis Aerobic Respiration Cellular Respiration
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Respiratory electron transport Mitochondrial protein degradation Complex III assembly Complex III assembly
Drugs		Chlortetracycline Fostamatinib	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN	3 interacting genes: CACNA1A RTN4 UQCRC1
Entrez ID		2047	7385
HPRD ID		02790	01876
Ensembl ID		ENSG00000154928	ENSG00000140740
Uniprot IDs		P54762	P22695
PDB IDs		2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW 7KPL 7KPM	5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Surface Receptor Signaling Pathway Vesicle Membrane Acid Phosphatase Activity Neuron Projection Development Neurotrophin TRKA Receptor Binding T Cell Costimulation T Cell Activation Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Pyrimidine-containing Compound Metabolic Process T Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cell-cell Junction Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Schwann Cell Development Lymphocyte Activation Positive Regulation Of Phosphorylation Positive Regulation Of T Cell Activation Cell Projection Organization Positive Regulation Of Cell Adhesion Lymphocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Mononuclear Cell Proliferation Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Presynaptic Membrane Leukocyte Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Insulin-like Growth Factor Receptor Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lymphocyte Activation Regulation Of Actin Cytoskeleton Organization Thiamine Phosphate Phosphatase Activity Signal Transduction Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity	Modulation Of Chemical Synaptic Transmission Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Cell Recognition Cell Projection Optic Nerve Morphogenesis Regulation Of Cell Junction Assembly Negative Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Synapse Assembly Negative Regulation Of Satellite Cell Differentiation Hindbrain Tangential Cell Migration Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Activation Quinol-cytochrome-c Reductase Activity Cell Migration Involved In Vasculogenesis Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Intracellular Sphingolipid Homeostasis Endoplasmic Reticulum Tubular Network Formation Central Nervous System Vasculogenesis Endoplasmic Reticulum Tubular Network Membrane Negative Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Endoplasmic Reticulum Tubular Network Membrane Organization Cerebral Cortex Radial Glia-guided Migration Positive Regulation Of Artery Morphogenesis Neuronal Cell Body Axon Guidance Receptor Activity Protein-containing Complex Binding Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Respiratory Chain Complex Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Artery Morphogenesis Positive Regulation Of Hepatocyte Proliferation Nuclear Pore Complex Assembly Cell Migration In Hindbrain High Voltage-gated Calcium Channel Activity Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Immunological Synapse Formation Cranial Nerve Morphogenesis Dendritic Spine Development Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Nervous System Development Ephrin Receptor Activity
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