EPHB1 and AADAC

		EPHB1	AADAC
Description		EPH receptor B1	arylacetamide deacetylase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Axon Dendrite Early Endosome Membrane Filopodium Tip Cell Projection Membrane Raft Extracellular Exosome Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Protein-containing Complex Binding	Catalytic Activity Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Serine Hydrolase Activity Deacetylase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Angiogenesis Immunological Synapse Formation Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Skeletal Muscle Satellite Cell Activation Cell Migration Cranial Nerve Development Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis System Development Modulation Of Chemical Synaptic Transmission Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation	Lipid Metabolic Process Xenobiotic Metabolic Process Positive Regulation Of Triglyceride Catabolic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Phase I - Functionalization of compounds
Drugs		Chlortetracycline Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Immunoglobulin A ( 20694011) Male-pattern baldness ( 28196072 29146897)
Interacting Genes		13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN	1 interacting genes: APPBP2
Entrez ID		2047	13
HPRD ID		02790	02640
Ensembl ID		ENSG00000154928	ENSG00000114771
Uniprot IDs		P54762	P22760
PDB IDs		2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW 7KPL 7KPM
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Surface Receptor Signaling Pathway Vesicle Membrane Acid Phosphatase Activity Neuron Projection Development Neurotrophin TRKA Receptor Binding T Cell Costimulation T Cell Activation Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Pyrimidine-containing Compound Metabolic Process T Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cell-cell Junction Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Schwann Cell Development Lymphocyte Activation Positive Regulation Of Phosphorylation Positive Regulation Of T Cell Activation Cell Projection Organization Positive Regulation Of Cell Adhesion Lymphocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Mononuclear Cell Proliferation Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Presynaptic Membrane Leukocyte Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Insulin-like Growth Factor Receptor Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lymphocyte Activation Regulation Of Actin Cytoskeleton Organization Thiamine Phosphate Phosphatase Activity Signal Transduction Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity	Filopodium Tip Optic Nerve Morphogenesis Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Proliferation Cell Migration In Hindbrain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Axon Guidance Receptor Activity Negative Regulation Of Satellite Cell Differentiation Immunological Synapse Formation Cranial Nerve Morphogenesis Hindbrain Tangential Cell Migration Dendritic Spine Development Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Dendritic Spine Morphogenesis Regulation Of Skeletal Muscle Satellite Cell Proliferation Ephrin Receptor Activity Skeletal Muscle Satellite Cell Activation Cul2-RING Ubiquitin Ligase Complex Detection Of Temperature Stimulus Involved In Sensory Perception Retinal Ganglion Cell Axon Guidance Detection Of Temperature Stimulus Regulation Of Skeletal Muscle Cell Differentiation Central Nervous System Projection Neuron Axonogenesis Camera-type Eye Morphogenesis Dendritic Spine Organization Cranial Nerve Development Central Nervous System Neuron Axonogenesis Microtubule Associated Complex Neuron Projection Organization Postsynapse Organization Nerve Development Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Synapse Assembly Eye Morphogenesis Cell-cell Recognition Microtubule Motor Activity Sensory Organ Morphogenesis Protein Modification Process Establishment Of Cell Polarity Neural Precursor Cell Proliferation
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