EPHB1 and CTPS1

Data Source: HiPPIP (Novel)

		EPHB1	CTPS1
Name		EPH receptor B1	CTP synthase 1
Structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Axon Dendrite Early Endosome Membrane Filopodium Tip Cell Projection Membrane Raft Extracellular Exosome Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Membrane Cytoophidium
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity Protein-containing Complex Binding	Nucleotide Binding CTP Synthase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding
	Biological Process	Angiogenesis Immunological Synapse Formation Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Skeletal Muscle Satellite Cell Activation Cell Migration Cranial Nerve Development Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Camera-type Eye Morphogenesis System Development Modulation Of Chemical Synaptic Transmission Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation	Immune System Process Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleotide Biosynthetic Process CTP Biosynthetic Process Response To Xenobiotic Stimulus Pyrimidine Nucleobase Biosynthetic Process T Cell Proliferation B Cell Proliferation 'de Novo' CTP Biosynthetic Process Small Molecule Metabolic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Interconversion of nucleotide di- and triphosphates
Drugs		Chlortetracycline Fostamatinib	L-Glutamine
GWAS		A body shape index ( 34021172 ) Adult body size ( 32376654 ) Bitter beverage consumption ( 31046077 ) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583 ) Daytime sleep phenotypes ( 27126917 ) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383 ) Familial lung adenocarcinoma ( 29924316 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Iron status biomarkers (total iron binding capacity) ( 28334935 ) Iron status biomarkers (transferrin saturation) ( 28334935 ) Mood instability ( 31168069 ) Neurofibrillary tangles ( 31497858 ) Small cell lung carcinoma ( 28604730 ) Visceral adipose tissue adjusted for BMI ( 22589738 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip ratio ( 28552196 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )	Heel bone mineral density ( 30598549 ) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928 )
Novel Interactors		10 novel interactors: AADAC ACP3 AMOTL2 CTPS1 GM2A GTF2E1 MBD4 MRPL3 PCCB UQCRC2	1 novel interactors: EPHB1
Interacting Genes		13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN	4 interacting genes: CEBPA LINC01554 YWHAG YWHAQ
Entrez ID		2047	1503
HPRD ID		02790	00465
Ensembl ID		ENSG00000154928	ENSG00000171793
Uniprot IDs		P54762	A0A3B3IRQ8 A0A3B3ITB8 B4E1E0 P17812
PDB IDs		2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW 7KPL 7KPM	2VO1 5U03 7MGZ 7MH0 7MIF 7MIG
GO Terms Enriched among Interactors		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Surface Receptor Signaling Pathway Vesicle Membrane Acid Phosphatase Activity Neuron Projection Development Neurotrophin TRKA Receptor Binding T Cell Costimulation T Cell Activation Regulation Of Cell-cell Adhesion Signal Complex Assembly Regulation Of Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Pyrimidine-containing Compound Metabolic Process T Cell Proliferation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cell-cell Junction Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Schwann Cell Development Lymphocyte Activation Positive Regulation Of Phosphorylation Positive Regulation Of T Cell Activation Cell Projection Organization Positive Regulation Of Cell Adhesion Lymphocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Mononuclear Cell Proliferation Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Presynaptic Membrane Leukocyte Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Insulin-like Growth Factor Receptor Signaling Pathway Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lymphocyte Activation Regulation Of Actin Cytoskeleton Organization Thiamine Phosphate Phosphatase Activity Signal Transduction Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity	Protein Domain Specific Binding