EPHA4 and NGEF

Number of citations of the paper that reports this interaction (PubMedID 11336673)
0

Data Source:
HPRD (in vivo, two hybrid)

		EPHA4	NGEF
Description		EPH receptor A4	neuronal guanine nucleotide exchange factor
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endosome Early Endosome Plasma Membrane Adherens Junction Cell Surface Postsynaptic Density Membrane Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Presynaptic Membrane Cell Projection Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Axonal Growth Cone Cell Body Synapse Postsynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytosol Membrane Growth Cone Cell Projection Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding Protein Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Glial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Negative Regulation Of Translation Corticospinal Tract Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Organization Regulation Of GTPase Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Translational Initiation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Innervation Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Cochlea Development Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Neuron Projection Guidance Synapse Pruning Neuron Projection Fasciculation Membraneless Organelle Assembly Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Modification Of Synaptic Structure Regulation Of Synapse Pruning	Nervous System Development Cell Differentiation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Pruning
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells Somitogenesis	NRAGE signals death through JNK EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26394188) Blond vs. brown/black hair color ( 30531825) Brain imaging ( 20100581) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cortical surface area (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Entorhinal cortical volume ( 31530798) Face memory ( 31596458) Hair color ( 29662168) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Nose size ( 27182965) Paclitaxel-induced neuropathy ( 23776197) Rostral anterior cingulate cortex volume ( 31530798) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels in lean individuals ( 25811787)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 28869591 30598549) Parkinson's disease ( 32201043) Pursuit maintenance gain ( 29064472) Schizophrenia ( 23974872 25056061 28991256 29483656 30285260) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		19 interacting genes: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 ERBB2 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF RNF5 SLA2 SRC TNS3	16 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK LCOR MRPL44 NUDT21 RHOA SH2D1A SMO TAF1D TRIM55 TRIM63 USP7
Entrez ID		2043	25791
HPRD ID		03719	10442
Ensembl ID		ENSG00000116106	ENSG00000066248
Uniprot IDs		E9PG71 P54764	B4DDI2 Q8N5V2
PDB IDs		2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2 7OFV 9CY8
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Activity Regulation Of Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation Neuron Projection Guidance Axon Guidance Protein Tyrosine Kinase Activity Neuron Projection Development Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Binding Regulation Of Developmental Process Positive Regulation Of Lipase Activity Cell Projection Organization Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation T Cell Costimulation Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Neuron Projection Development Signal Transduction Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Positive Regulation Of MAPK Cascade Transmembrane-ephrin Receptor Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Protein Kinase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Cell Differentiation Protein Phosphorylation
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