EPHA4 and EFNA4

Number of citations of the paper that reports this interaction (PubMedID 10366629)
93

Data Source:
HPRD (in vivo)

		EPHA4	EFNA4
Description		EPH receptor A4	ephrin A4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endosome Early Endosome Plasma Membrane Adherens Junction Cell Surface Postsynaptic Density Membrane Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Presynaptic Membrane Cell Projection Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Axonal Growth Cone Cell Body Synapse Postsynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding Protein Tyrosine Kinase Binding	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Glial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Negative Regulation Of Translation Corticospinal Tract Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Organization Regulation Of GTPase Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Translational Initiation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Innervation Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Cochlea Development Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Neuron Projection Guidance Synapse Pruning Neuron Projection Fasciculation Membraneless Organelle Assembly Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Modification Of Synaptic Structure Regulation Of Synapse Pruning	Cell-cell Signaling Axon Guidance Ephrin Receptor Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells Somitogenesis	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26394188) Blond vs. brown/black hair color ( 30531825) Brain imaging ( 20100581) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cortical surface area (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Entorhinal cortical volume ( 31530798) Face memory ( 31596458) Hair color ( 29662168) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Nose size ( 27182965) Paclitaxel-induced neuropathy ( 23776197) Rostral anterior cingulate cortex volume ( 31530798) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels in lean individuals ( 25811787)	Adventurousness ( 30643258) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 ERBB2 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF RNF5 SLA2 SRC TNS3	10 interacting genes: EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 MAP2K4 TMEM147 TRARG1
Entrez ID		2043	1945
HPRD ID		03719	03224
Ensembl ID		ENSG00000116106	ENSG00000243364
Uniprot IDs		E9PG71 P54764	P52798
PDB IDs		2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2 7OFV 9CY8
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Activity Regulation Of Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation Neuron Projection Guidance Axon Guidance Protein Tyrosine Kinase Activity Neuron Projection Development Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Binding Regulation Of Developmental Process Positive Regulation Of Lipase Activity Cell Projection Organization Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation T Cell Costimulation Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Neuron Projection Development Signal Transduction Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Positive Regulation Of MAPK Cascade Transmembrane-ephrin Receptor Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Protein Kinase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Cell Differentiation Protein Phosphorylation	Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway GPI-linked Ephrin Receptor Activity Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Regulation Of GTPase Activity Cell Surface Receptor Signaling Pathway Dendrite ATP Binding Plasma Membrane Bounded Cell Projection Organization Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Cell Projection Organization Nucleotide Binding Transferase Activity Growth Factor Binding Positive Regulation Of Protein Localization To Plasma Membrane Nephric Duct Morphogenesis Plasma Membrane Regulation Of Catalytic Activity Positive Regulation Of Protein Localization To Cell Periphery Neuromuscular Junction Regulation Of Synapse Pruning Positive Regulation Of Protein Localization To Membrane Schaffer Collateral - CA1 Synapse Regulation Of Protein Localization To Plasma Membrane Axonal Fasciculation Neuron Projection Fasciculation Regulation Of Cell Adhesion Regulation Of Protein Localization To Cell Periphery Cell Adhesion Signal Transduction Cell Migration Ephrin Receptor Binding Regulation Of Protein Localization To Membrane Regulation Of Cellular Localization System Development Cell Motility Protein Tyrosine Kinase Binding Nervous System Development Neuron Recognition Regulation Of Cell Adhesion Mediated By Integrin
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