EPHA4 and FYN

Number of citations of the paper that reports this interaction (PMID 12084815)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EPHA4	FYN
Gene Name		EPH receptor A4	FYN proto-oncogene, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Cell Junction Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Dendritic Spine Perikaryon Axon Terminus Axonal Growth Cone Postsynaptic Membrane	Nucleus Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft
	Molecular Function	Protein Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding	G-protein Coupled Receptor Binding Glycoprotein Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Tubulin Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Phosphatidylinositol 3-kinase Binding Ion Channel Binding Metal Ion Binding Ephrin Receptor Binding Peptide Hormone Receptor Binding Growth Factor Receptor Binding
	Biological Process	Cell Adhesion Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Glial Cell Migration Peptidyl-tyrosine Phosphorylation Corticospinal Tract Morphogenesis Regulation Of Rac GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Dendritic Spine Morphogenesis Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity	Neuron Migration Protein Phosphorylation Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Blood Coagulation Learning Feeding Behavior Regulation Of Cell Shape Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Cell Migration Cell Differentiation Platelet Activation Forebrain Development T Cell Costimulation Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Dendrite Morphogenesis Regulation Of Defense Response To Virus By Virus Activated T Cell Proliferation T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease DCC mediated attractive signaling Netrin mediated repulsion signals Signaling by EGFRvIII in Cancer Nef and signal transduction Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Regulation of KIT signaling PI3K/AKT activation PI-3K cascade EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Signaling by PDGF DAP12 interactions GAB1 signalosome Host Interactions of HIV factors CD28 co-stimulation CD28 dependent PI3K/Akt signaling The role of Nef in HIV-1 replication and disease pathogenesis Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Signaling by VEGF Downstream signal transduction Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Platelet Adhesion to exposed collagen Axon guidance Costimulation by the CD28 family PIP3 activates AKT signaling HIV Infection VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse Ephrin signaling EPH-ephrin mediated repulsion of cells PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR NCAM signaling for neurite out-growth Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Semaphorin interactions CTLA4 inhibitory signaling Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer PECAM1 interactions CD28 dependent Vav1 pathway Signaling by FGFR Cell surface interactions at the vascular wall GPVI-mediated activation cascade
Drugs			Dasatinib 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane
Diseases
GWAS		Brain imaging ( 20100581) Paclitaxel-induced neuropathy ( 23776197)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		15 interactors: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF SRC	182 interactors: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DOK1 DOK3 DOK4 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 EVL FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB GAB3 GNB2L1 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B HNRNPK HRAS HSP90AA1 HTR6 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCP2 MAG MAP2 MAPT MCAM MED28 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RAF1 RPL10 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70
Entrez ID		2043	2534
HPRD ID		03719	00655
Ensembl ID		ENSG00000116106	ENSG00000010810
Uniprot IDs		E9PG71 P54764 Q58F15	P06241 Q5R3A8
PDB IDs		2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF	1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Axon Guidance Neuron Development Peptidyl-tyrosine Phosphorylation Cell Morphogenesis Neuron Differentiation Cell Projection Organization Chemotaxis Generation Of Neurons Neurogenesis Cell Surface Receptor Signaling Pathway Locomotion Anatomical Structure Morphogenesis Cell Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Nervous System Development Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction System Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To External Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Cell-cell Signaling Response To Fibroblast Growth Factor Peptidyl-amino Acid Modification Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Multicellular Organismal Development Anatomical Structure Development Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Phosphorylation	Signaling Signal Transduction Cell Communication Regulation Of Immune System Process Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Locomotion Regulation Of Signal Transduction Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Defense Response Positive Regulation Of Signal Transduction Innate Immune Response Cell Activation Blood Coagulation Antigen Receptor-mediated Signaling Pathway Hemostasis Fc Receptor Signaling Pathway Response To Wounding Response To Stress Wound Healing Response To Organic Substance Cell Migration Cell Differentiation Intracellular Signal Transduction Cell Motility Regulation Of Body Fluid Levels Response To External Stimulus Regulation Of Cellular Process Developmental Process Regulation Of Cell-cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorylation Anatomical Structure Development Regulation Of Cell Activation Regulation Of Cellular Component Organization
Tagcloud ?		abl adaptor aml1 amongst arising betapdgf chimeric coding dimerization elicits ets folding gtpases hetero homo homodimer homophilic module oligomerize oncogenic property reveals sam scaffolding shared sterile tel threonine	293t analyzing anchoring aspartate binds coclusters coexpressed family implicated involves learning lyn mediate member nmda nr2a participates plasticity promotes psd ptk ptks scaffold serving src substrate synaptic tyrosine yes
Tagcloud (Difference) ?		abl adaptor aml1 amongst arising betapdgf chimeric coding dimerization elicits ets folding gtpases hetero homo homodimer homophilic module oligomerize oncogenic property reveals sam scaffolding shared sterile tel threonine	293t analyzing anchoring aspartate binds coclusters coexpressed family implicated involves learning lyn mediate member nmda nr2a participates plasticity promotes psd ptk ptks scaffold serving src substrate synaptic tyrosine yes
Tagcloud (Intersection) ?