ARNT2 and NPAS4

Number of citations of the paper that reports this interaction (PubMedID 14701734)
32

Data Source:
HPRD (two hybrid)

		ARNT2	NPAS4
Description		aryl hydrocarbon receptor nuclear translocator 2	neuronal PAS domain protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Aryl Hydrocarbon Receptor Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Postsynapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Response To Hypoxia In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Response To Estradiol Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Nervous System Development Learning Short-term Memory Long-term Memory Cell Differentiation Regulation Of Synaptic Transmission, GABAergic Cellular Response To Stress Social Behavior Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Cellular Response To Corticosterone Stimulus Inhibitory Synapse Assembly
Pathways		PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes	Regulation of NPAS4 mRNA translation NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015 30061737) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder ( 20351715) Body mass index ( 26426971) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Bipolar disorder ( 21926972) General risk tolerance (MTAG) ( 30643258) Left-handedness ( 32989287) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		69 interacting genes: ADAMTSL4 AHR AP1M1 AP3M1 APP ARNT CALCOCO2 CAPN7 CCDC33 CDR2 CEP57L1 CEP63 CTBP1 DGCR6 DTX2 DYDC1 EPAS1 FAAP20 GOLGA2 HIF1A IKZF3 KIFC3 LMO2 LMO4 LZTS2 MAGEA4 MAGED1 MEIS2 MEOX2 MIPOL1 MTDH MTUS2 NCOA3 NDE1 NPAS2 NPAS4 OSGIN1 PDE4DIP PLSCR1 PSMB1 RBCK1 REL RFX6 RIMBP3 RINT1 SH3GL2 SIM1 SORBS3 SPAG5 SSBP3 SSX2IP STK16 SYCE1 TACC3 TADA2A TAX1BP3 TFIP11 TRAF1 TRAF2 TRIM23 TRIM27 TRIM37 TRIM42 TRIP6 TSPOAP1 USHBP1 USP7 VPS52 ZNF341	4 interacting genes: ARNT ARNT2 BMAL1 MAGED1
Entrez ID		9915	266743
HPRD ID		06915	12260
Ensembl ID		ENSG00000172379	ENSG00000174576
Uniprot IDs		Q86TN1 Q9HBZ2 X5DQN9	Q8IUM7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Protein Dimerization Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Nuclear Aryl Hydrocarbon Receptor Complex Nucleus Microtubule Organizing Center Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Centrosome Protein Heterodimerization Activity DNA-binding Transcription Factor Activity Chromatin Microtubule-based Process Positive Regulation Of Autophagy Regulation Of Primary Metabolic Process Establishment Of Localization In Cell Benzodiazepine Receptor Binding Positive Regulation Of Glycolytic Process Embryonic Placenta Development Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Intracellular Transport Regulation Of Gene Expression Tumor Necrosis Factor Receptor Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Metabolic Process Intestinal Epithelial Structure Maintenance Positive Regulation Of ATP Metabolic Process Microtubule RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Identical Protein Binding	Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Protein Dimerization Activity Transcription Regulator Complex Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Circadian Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Transcription By RNA Polymerase II Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Oxidative Stress-induced Premature Senescence DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CLOCK-BMAL Transcription Complex Rhythmic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Acetylation Stress-induced Premature Senescence Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Hypoxia Positive Regulation Of Developmental Process Response To Decreased Oxygen Levels Intestinal Epithelial Structure Maintenance Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Response To Oxygen Levels Protein Heterodimerization Activity Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Sumoylation Chromatoid Body Regulation Of Cell Population Proliferation Response To Redox State Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
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