MAP6 and RORB

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
HPRD (two hybrid)

		MAP6	RORB
Description		microtubule associated protein 6	RAR related orphan receptor B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Golgi-associated Vesicle Cis-Golgi Network Cytoskeleton Microtubule Membrane Axon Dendrite Transport Vesicle Membrane Cytoplasmic Vesicle Cell Projection Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Calmodulin Binding Microtubule Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Melatonin Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Lysosome Localization Dendrite Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Microtubule Cytoskeleton Organization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Amacrine Cell Differentiation Eye Photoreceptor Cell Development Regulation Of Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development Retinal Cone Cell Development Rhythmic Process Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Cellular Response To Retinoic Acid
Pathways			Nuclear Receptor transcription pathway Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Melatonin
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Alcohol consumption (drinks per week) ( 30643258) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Chronotype ( 30696823) Hyperopia ( 33830181) Immature fraction of reticulocytes ( 32888494) Low myopia vs hyperopia ( 33830181) Macular thickness ( 30535121) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		7 interacting genes: GRSF1 NR2F1 RARB RARG RORB TRAF1 TUBB	36 interacting genes: ANKS1A CLOCK CRACR2A CSNK2B DELEC1 FBXO7 GAS2L2 KRTAP4-5 LCK LCOR MAP6 MED25 MID2 MTCL2 NCOA1 NCOA6 NME1 NME2 NPPA NRIP1 NRIP2 NSD1 PNRC1 PNRC2 PSMC4 PSMC5 RORC SCNM1 SMARCD1 TEKT5 TLE5 TNNI2 TSGA10IP UBE2I ZNF417 ZNF587
Entrez ID		4135	6096
HPRD ID		15989	09062
Ensembl ID		ENSG00000171533	ENSG00000198963
Uniprot IDs		Q96JE9	A0A1L4FMK7 Q58EY0 Q92753
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Glandular Epithelial Cell Development Intracellular Receptor Signaling Pathway Growth Plate Cartilage Development Nuclear Retinoid X Receptor Binding Sequence-specific DNA Binding Columnar/cuboidal Epithelial Cell Development Cartilage Development Involved In Endochondral Bone Morphogenesis Negative Regulation Of Chondrocyte Differentiation Sequence-specific Double-stranded DNA Binding Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Stem Cell Proliferation Embryonic Hindlimb Morphogenesis Embryonic Eye Morphogenesis Negative Regulation Of Cartilage Development DNA-binding Transcription Factor Activity Hindlimb Morphogenesis Regulation Of Myelination Regulation Of Chondrocyte Differentiation Positive Regulation Of RNA Metabolic Process Eye Morphogenesis Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Sensory Organ Morphogenesis Regulation Of Cartilage Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Connective Tissue Development Bone Development Cellular Response To Retinoic Acid Stem Cell Proliferation Embryonic Morphogenesis Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Limb Morphogenesis Cartilage Development Multicellular Organism Growth Nuclear Receptor-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Retinoic Acid Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Organ Morphogenesis Positive Regulation Of Mitochondrial RNA Catabolic Process Epithelial Cell Development RNA Polymerase II Transcription Regulator Complex Growth Plate Cartilage Chondrocyte Growth Negative Regulation Of RNA Metabolic Process	Nuclear Retinoid X Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Regulation Of Metabolic Process ITP Biosynthetic Process Protein Histidine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process ITP Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Proteasome-activating Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process UTP Biosynthetic Process Nuclear Receptor Binding Regulation Of Macromolecule Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Signaling Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process CTP Biosynthetic Process Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Macromolecule Biosynthetic Process CTP Metabolic Process Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Circadian Regulation Of Gene Expression Protein Localization To Microtubule Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteasome Accessory Complex Negative Regulation Of Transcription By RNA Polymerase II Transcription Factor Binding Positive Regulation Of Circadian Rhythm GTP Metabolic Process Transcription Corepressor Activity Pyrimidine Ribonucleotide Biosynthetic Process Macromolecule Catabolic Process
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