ENO1 and UBE3A

Number of citations of the paper that reports this interaction (PubMedID 31329371)
0

Data Source:
BioGRID (pull down)

		ENO1	UBE3A
Description		enolase 1	ubiquitin protein ligase E3A
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GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Nuclear Outer Membrane Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane M Band Extracellular Exosome	Proteasome Complex Nucleus Cytoplasm Cytosol Synaptic Vesicle Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding GTPase Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Negative Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Protein Polyubiquitination Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels Response To Progesterone Sperm Entry Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Animal Organ Development System Development Modulation Of Chemical Synaptic Transmission Progesterone Receptor Signaling Pathway Protein Autoubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Golgi Lumen Acidification Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)	Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)
Interacting Genes		66 interacting genes: AGTPBP1 ALDOA AMBP ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CHKA CLK1 COL14A1 CYSLTR2 DES DRC2 DUX4 FANCA FHL1 FLNC FNDC3B FXR1 FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 OGT P4HB PAF1 PCNA PDE4B PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TRAPPC2 TTN TUBA1A UBE3A UPF2 YWHAQ YWHAZ ZBTB44	165 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ALDH1A2 ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BAK1 BARD1 BLK BPY2 BPY2B BPY2C BRCA1 CALR CAPN3 CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CKB CRP CSTPP1 CTNNB1 DAZAP2 DDI2 DLG1 DLG4 E2F1 EAPP EEF1A2 EID1 EIF4G1 EML1 ENO1 ENO2 ESR1 FAF2 GFAP GOPC GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA2 HSPA4 HSPA5 IL24 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK LCN2 MAGEA12 MAGEA8 MAPK1 MAPK10 MARF1 MCM2 MCM4 MCM6 MCM7 MDM1 MDM2 MDM4 MEOX2 MSTO1 MYCBP MYCN NBPF14 NDUFA13 NELFCD NFX1 NHERF1 NOMO2 NR3C1 NR4A3 NUMBL PAICS PARVA PAX5 PAX6 PBRM1 PDE1B PDIA3 PDIA6 PGK1 PGR PKM PML POLE4 PPIA PPP1R3F PRAG1 PRDX1 PRKACA PRMT5 PRSS1 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RNF152 RNF2 RPS15A RYBP SACS SCAMP1 SCRIB SERPINB2 SET SHBG SIPA1L1 SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 TUBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN2 UBR5 WBP2 WDR4 YOD1 YWHAE YWHAG ZNF250 ZNF446
Entrez ID		2023	7337
HPRD ID		01400	03375
Ensembl ID		ENSG00000074800	ENSG00000114062
Uniprot IDs		A0A024R4F1 A0A2R8Y6G6 P06733	A0A6Q8PHE5 Q05086 Q9H2G0
PDB IDs		2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK 8TRL	1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19 7Q41 7QPB 8ENP 8EPT 8GCR 8JRN 8JRO 8JRP 8JRQ 8JRR 8R1F 8R1G 9CHT
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Organelle Organization Negative Regulation Of Immune Response Muscle Hypertrophy Developmental Process Negative Regulation Of Apoptotic Process Cytoskeletal Protein Binding Negative Regulation Of Programmed Cell Death Z Disc Titin-telethonin Complex Sarcomerogenesis Negative Regulation Of Transcription By RNA Polymerase II Muscle Structure Development Sarcomere Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Costamere Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process T Cell Costimulation Identical Protein Binding Negative Regulation Of Biosynthetic Process Regulation Of Membrane Depolarization Regulation Of Metabolic Process Regulation Of Programmed Cell Death Skeletal Muscle Myosin Thick Filament Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To L-glutamate Regulation Of Gene Expression Rhythmic Process Sarcolemma Negative Regulation Of Rho Protein Signal Transduction Regulation Of DNA-templated Transcription Actomyosin Structure Organization Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of RNA Biosynthetic Process Myosin Filament Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Tubulin Binding Cytoskeleton Organization	Cytosol Nucleus Cytoplasm Ubiquitin Protein Ligase Binding Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Nucleoplasm Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Response To Stress Protein-containing Complex Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Extracellular Exosome Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Nuclear Receptor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Binding Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Enzyme Binding Identical Protein Binding Regulation Of DNA-templated Transcription
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