LINC01554 and HSPD1

Number of citations of the paper that reports this interaction (PubMedID 30809309)
42

Data Source:
BioGRID (unspecified method)

		LINC01554	HSPD1
Description		long intergenic non-protein coding RNA 1554	heat shock protein family D (Hsp60) member 1
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Coated Vesicle Secretory Granule Protein-containing Complex Intracellular Membrane-bounded Organelle Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece Sperm Plasma Membrane Migrasome
	Molecular Function		Nucleotide Binding Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Protein-folding Chaperone Binding Cysteine-type Endopeptidase Activator Activity ATP-dependent Protein Folding Chaperone
	Biological Process		Positive Regulation Of Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Folding 'de Novo' Protein Folding Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Positive Regulation Of Interferon-alpha Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Mitochondrial Unfolded Protein Response Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation Biological Process Involved In Interaction With Symbiont Cellular Response To Interleukin-7 Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways			Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs			Copper
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS		LDL cholesterol levels in HIV infection ( 33109212)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		141 interacting genes: AARS1 ACADVL ACIN1 ACTB ACTG1 ACTN1 ACTN3 ACTR3 ALDOA ANXA2 ANXA5 ANXA6 APEX1 ARHGAP1 ASS1 ATAD3A ATIC ATP5F1A BZW2 CANX CCT2 CCT3 CCT4 CCT6A CCT7 CKAP4 CS CTPS1 DDX3X DDX46 DHX9 DNAH2 DNAJA1 DST DYNC1H1 EDARADD EEF1G EEF2 EIF3A EIF3E EIF4A2 EIF4B ENO1 ENO3 EPRS1 ERO1A G3BP1 G6PD GANAB GAPDH GARS1 GDI2 GPI GTF2I HIVEP2 HMCN1 HNRNPF HSP90AA1 HSP90B1 HSPA1L HSPA5 HSPA8 HSPA9 HSPD1 HYOU1 IDH1 IPO4 IPO7 IPO9 ITPR2 KARS1 KPNA1 KPNB1 KRT18 KRT7 KRT8 KRT8P3 LRPPRC MCM7 MSN MYO18A NAP1L1 NAP1L4 NCBP1 NCL NPM1 OLA1 OXCT1 PABPC1 PCBP2 PDIA3 PDIA6 PFAS PGD PGK1 PGM1 PHGDH PKM PLOD2 PMPCA POR PPP2R1A PSMC1 PSMD2 PSMD7 PTBP1 RDX RPL6 RPSA RTCB RTN4 SARS1 SEPTIN7 SEPTIN9 SERPINH1 SFPQ SQSTM1 TARS1 TGFBI THOP1 TKT TTF2 TUBA1A TUBA8 TUBB TUBB2A TUBB3 TUBB4A TUBB4B TUBB6 TUFM TXNRD1 TYMP UBA1 VCL VCP VIM VPS35 WARS1 XPO1 XRCC5	58 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CFTR CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT FNDC3B H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 OGT PDE4B PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG
Entrez ID		202299	3329
HPRD ID		16896	00318
Ensembl ID		ENSG00000236882	ENSG00000144381
Uniprot IDs			A0A024R3X4 P10809
PDB IDs			4PJ1 6HT7 6MRC 6MRD 7AZP 7L7S 8G7J 8G7K 8G7L 8G7M 8G7N 8G7O 8U39
Enriched GO Terms of Interacting Partners?		Extracellular Exosome RNA Binding Nucleotide Binding Cytosol Cytoplasm Unfolded Protein Binding ATP-dependent Protein Folding Chaperone ATP Hydrolysis Activity ATP Binding Focal Adhesion Protein Folding Secretory Granule Lumen Cadherin Binding Ficolin-1-rich Granule Lumen Protein Folding Chaperone Structural Constituent Of Cytoskeleton Nucleotide Metabolic Process Nicotinamide Nucleotide Metabolic Process Microtubule Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process Ligase Activity Melanosome Purine Nucleotide Metabolic Process Nucleoside Phosphate Metabolic Process Protein Refolding Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Positive Regulation Of Telomerase RNA Localization To Cajal Body Ribose Phosphate Metabolic Process ADP Catabolic Process Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex ATP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoprotein Complex Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Nucleotide Catabolic Process Nucleoside Diphosphate Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Ribonucleotide Metabolic Process Microtubule Cytoskeleton Protein Folding In Endoplasmic Reticulum Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance Via Telomerase Nucleobase-containing Compound Catabolic Process Translation TRNA Aminoacylation	Protein-folding Chaperone Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Signaling Cytosol Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Signal Transduction Regulation Of Proteolysis Regulation Of Calcium-mediated Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Adhesion Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Signaling Identical Protein Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-2 Production Protein Heterodimerization Activity Regulation Of Protein Localization Glutamatergic Synapse Response To Stress Regulation Of Cytokine Production Fibroblast Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Proteolysis Regulation Of Reactive Oxygen Species Metabolic Process Integrin Alpha3-beta1 Complex Membrane Raft Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Neuron Projection Organization Regulation Of Programmed Cell Death Response To Yeast Cognition Regulation Of Cellular Localization Keratin Filament Regulation Of Multicellular Organismal Process
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