LINC01554 and PHGDH

Number of citations of the paper that reports this interaction (PubMedID 30809309)
42

Data Source:
BioGRID (unspecified method)

		LINC01554	PHGDH
Description		long intergenic non-protein coding RNA 1554	phosphoglycerate dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component		Cytosol Extracellular Exosome
	Molecular Function		Phosphoglycerate Dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity NAD Binding
	Biological Process		Glutamine Metabolic Process Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Amino Acid Biosynthetic Process Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Neurogenesis Neuron Projection Development G1 To G0 Transition
Pathways			Serine metabolism
Drugs			NADH
Diseases
GWAS		LDL cholesterol levels in HIV infection ( 33109212)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Glycine levels ( 31070104 30837465) Height ( 25282103) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Macular telangiectasia type 2 ( 33654266 28250457) Mean corpuscular hemoglobin ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 23378610) Multiple sclerosis ( 31604244 24076602) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Red blood cell count ( 27863252 32888494) Serum metabolite levels ( 33031748) Severe gingival inflammation ( 28459102) Total cholesterol levels ( 30275531)
Interacting Genes		141 interacting genes: AARS1 ACADVL ACIN1 ACTB ACTG1 ACTN1 ACTN3 ACTR3 ALDOA ANXA2 ANXA5 ANXA6 APEX1 ARHGAP1 ASS1 ATAD3A ATIC ATP5F1A BZW2 CANX CCT2 CCT3 CCT4 CCT6A CCT7 CKAP4 CS CTPS1 DDX3X DDX46 DHX9 DNAH2 DNAJA1 DST DYNC1H1 EDARADD EEF1G EEF2 EIF3A EIF3E EIF4A2 EIF4B ENO1 ENO3 EPRS1 ERO1A G3BP1 G6PD GANAB GAPDH GARS1 GDI2 GPI GTF2I HIVEP2 HMCN1 HNRNPF HSP90AA1 HSP90B1 HSPA1L HSPA5 HSPA8 HSPA9 HSPD1 HYOU1 IDH1 IPO4 IPO7 IPO9 ITPR2 KARS1 KPNA1 KPNB1 KRT18 KRT7 KRT8 KRT8P3 LRPPRC MCM7 MSN MYO18A NAP1L1 NAP1L4 NCBP1 NCL NPM1 OLA1 OXCT1 PABPC1 PCBP2 PDIA3 PDIA6 PFAS PGD PGK1 PGM1 PHGDH PKM PLOD2 PMPCA POR PPP2R1A PSMC1 PSMD2 PSMD7 PTBP1 RDX RPL6 RPSA RTCB RTN4 SARS1 SEPTIN7 SEPTIN9 SERPINH1 SFPQ SQSTM1 TARS1 TGFBI THOP1 TKT TTF2 TUBA1A TUBA8 TUBB TUBB2A TUBB3 TUBB4A TUBB4B TUBB6 TUFM TXNRD1 TYMP UBA1 VCL VCP VIM VPS35 WARS1 XPO1 XRCC5	11 interacting genes: APP CEBPA CHMP2B LINC01554 MAPK6 OGT PIAS4 PJA1 SIRT2 SUMO4 TTN
Entrez ID		202299	26227
HPRD ID		16896	06047
Ensembl ID		ENSG00000236882	ENSG00000092621
Uniprot IDs			O43175
PDB IDs			2G76 5N53 5N6C 5NZO 5NZP 5NZQ 5OFM 5OFV 5OFW 6CWA 6PLF 6PLG 6RIH 6RJ2 6RJ3 6RJ5 6RJ6 7CVP 7DKM 7EWH 7VA1
Enriched GO Terms of Interacting Partners?		Extracellular Exosome RNA Binding Nucleotide Binding Cytosol Cytoplasm Unfolded Protein Binding ATP-dependent Protein Folding Chaperone ATP Hydrolysis Activity ATP Binding Focal Adhesion Protein Folding Secretory Granule Lumen Cadherin Binding Ficolin-1-rich Granule Lumen Protein Folding Chaperone Structural Constituent Of Cytoskeleton Nucleotide Metabolic Process Nicotinamide Nucleotide Metabolic Process Microtubule Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process Ligase Activity Melanosome Purine Nucleotide Metabolic Process Nucleoside Phosphate Metabolic Process Protein Refolding Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Positive Regulation Of Telomerase RNA Localization To Cajal Body Ribose Phosphate Metabolic Process ADP Catabolic Process Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex ATP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoprotein Complex Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Nucleotide Catabolic Process Nucleoside Diphosphate Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Ribonucleotide Metabolic Process Microtubule Cytoskeleton Protein Folding In Endoplasmic Reticulum Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance Via Telomerase Nucleobase-containing Compound Catabolic Process Translation TRNA Aminoacylation	Positive Regulation Of Proteolysis Negative Regulation Of RNA Biosynthetic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Negative Regulation Of RNA Metabolic Process Nuclear Membrane Reassembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Transferase Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Membrane Organization Membrane Assembly Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Positive Regulation Of Binding Regulation Of DNA Binding Protein Sumoylation Regulation Of Synapse Organization Regulation Of Carbohydrate Catabolic Process Autophagy Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Cognition Protein-containing Complex Organization Response To Metal Ion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Process
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