SPATA24 and PTAFR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SPATA24	PTAFR
Gene Name		spermatogenesis associated 24	platelet-activating factor receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Homodimerization Activity	Lipopolysaccharide Binding Lipopolysaccharide Receptor Activity G-protein Coupled Receptor Activity Platelet Activating Factor Receptor Activity Phospholipid Binding G-protein Coupled Purinergic Nucleotide Receptor Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Cell Differentiation	Cytokine Production Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Inositol Trisphosphate Biosynthetic Process G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Interferon-gamma-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Interferon Signaling Cytokine Signaling in Immune system Metabolic disorders of biological oxidation enzymes GPCR ligand binding Interferon gamma signaling G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CALCOCO2 CAMK2D CEP72 EHD2 FLOT2 KDM1A KRT31 KRT40 KRTAP4-2 LZTS2 MID2 PTAFR SUV39H1	9 interactors: ARR3 ARRB1 ARRB2 CALM1 GORAB GTPBP3 RGS4 SPATA24 TYK2
Entrez ID		202051	5724
HPRD ID		19510	01422
Ensembl ID		ENSG00000170469	ENSG00000169403
Uniprot IDs		Q86W54	A8K7N8 P25105
PDB IDs			2B0X
Enriched GO Terms of Interacting Partners?		Response To Interferon-gamma Response To Stress Innate Immune Response Regulation Of Primitive Erythrocyte Differentiation Establishment Of Protein Localization To Plasma Membrane Gamma-tubulin Complex Localization Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Cardiac Muscle Cell Contraction Interferon-gamma-mediated Signaling Pathway Regulation Of Histone Modification Spindle Organization Immune System Process Regulation Of Generation Of L-type Calcium Current Inositol Trisphosphate Biosynthetic Process Cellular Response To Interferon-gamma Immune Response Protein Localization To Plasma Membrane Positive Regulation Of Rac Protein Signal Transduction Regulation Of Histone Deacetylase Activity Negative Regulation Of Gene Expression Defense Response Cellular Protein Localization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Muscle Cell Development Cellular Localization Histone H3-K9 Dimethylation Negative Regulation Of Sodium Ion Transmembrane Transport Inositol Phosphate Biosynthetic Process Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Regulation Of Cardiac Muscle Cell Action Potential Histone H3-K4 Demethylation Protein Localization To Microtubule Response To Cytokine Positive Regulation Of Endocytic Recycling Inositol Trisphosphate Metabolic Process Regulation Of Relaxation Of Muscle Cellular Potassium Ion Homeostasis Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Growth Involved In Cardiac Muscle Cell Development Plasma Membrane Organization Positive Regulation Of Megakaryocyte Differentiation Regulation Of Endocytic Recycling Spindle Midzone Assembly Establishment Of Protein Localization To Membrane Histone H3-K9 Trimethylation	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Internalization Regulation Of Protein Phosphorylation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Detection Of Abiotic Stimulus Regulation Of Phosphorylation Platelet Activation Regulation Of Receptor Internalization Regulation Of Phosphorus Metabolic Process Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cellular Protein Metabolic Process Receptor Internalization Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Calcium Ion Transport Phototransduction Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Endocytosis Detection Of Light Stimulus Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Detection Of Stimulus Regulation Of Body Fluid Levels Vesicle-mediated Transport Positive Regulation Of ERK1 And ERK2 Cascade Wound Healing Regulation Of MAPK Cascade Regulation Of Signal Transduction Notch Signaling Pathway Regulation Of Protein Binding Endocytosis Cell Activation Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?			10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl purinergic sell selplg slc29a1 slc29a2
Tagcloud (Difference) ?			10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl purinergic sell selplg slc29a1 slc29a2
Tagcloud (Intersection) ?