SPATA24 and CTNNBIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPATA24	CTNNBIP1
Description		spermatogenesis associated 24	catenin beta interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Beta-catenin Destruction Complex Protein-containing Complex Beta-catenin-ICAT Complex
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding	Transcription Coactivator Binding Protein Binding Beta-catenin Binding Armadillo Repeat Domain Binding Transcription Regulator Inhibitor Activity
	Biological Process	Spermatogenesis Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Negative Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Malaria ( 31844061)	Platelet distribution width ( 32888494) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		24 interacting genes: CALCOCO2 CAMK2D CEP72 CTNNBIP1 CYSRT1 EFEMP2 EHD2 FLOT2 KDM1A KRT31 KRT40 KRTAP10-1 KRTAP10-7 KRTAP10-8 KRTAP4-2 LZTS2 MDFI MID2 NBPF19 NOTCH2NLA OIP5 PLEKHF2 PTAFR SUV39H1	19 interacting genes: BEND5 CTNNA2 CTNNB1 EMD GINS4 INCA1 JUP KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP5-9 MSS51 NBPF19 NOTCH2NLA P4HA3 REL SPATA24 TCF7L2 USHBP1
Entrez ID		202051	56998
HPRD ID		19510	09677
Ensembl ID		ENSG00000170469	ENSG00000178585
Uniprot IDs		Q86W54	Q9NSA3
PDB IDs			1LUJ 1M1E 1T08
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Identical Protein Binding	Catenin-TCF7L2 Complex Intermediate Filament Catenin Complex Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-TCF7L2 Complex Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Proteoglycan Biosynthetic Process Cellular Response To Indole-3-methanol Protein-DNA Complex Response To Indole-3-methanol Nuclear Receptor Binding Alpha-catenin Binding Presynaptic Active Zone Cytoplasmic Component Beta-catenin-TCF Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Fibroblast Proliferation Keratin Filament Postsynaptic Density, Intracellular Component Canonical Wnt Signaling Pathway Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Cadherin Binding Pancreas Development Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Wnt Signaling Pathway Regulation Of Glycoprotein Biosynthetic Process Adherens Junction Detection Of Mechanical Stimulus Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation TMEM240-body Gamma-catenin-TCF7L2 Complex Intercalated Disc Transcription Corepressor Binding Skin Development Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Positive Regulation Of Nucleocytoplasmic Transport
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