TMEM154 and FXYD6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM154	FXYD6
Description		transmembrane protein 154	FXYD domain containing ion transport regulator 6
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane Presynaptic Membrane Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity
	Biological Process		Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Regulation Of Monoatomic Ion Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways			Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) Hip circumference ( 28552196) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507) Type 2 diabetes ( 24509480 28869590 29358691 30054458 30297969 30718926 32499647)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)
Interacting Genes		11 interacting genes: CLCA4 CTSA CYB561D2 FUNDC2 FXYD6 GET3 GYPA MIP SGTA SLC35A4 SMIM1	67 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35E1 SLC35E3 SLC35H1 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119
Entrez ID		201799	53826
HPRD ID		08719	09456
Ensembl ID		ENSG00000170006	ENSG00000137726
Uniprot IDs		Q6P9G4	Q9H0Q3
PDB IDs			8D3U 8D3V 8D3W 8D3X 8D3Y
Enriched GO Terms of Interacting Partners?		Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Membrane Lumenal Side Of Lysosomal Membrane TRC Complex GET Complex Negative Regulation Of Chaperone-mediated Autophagy Ascorbate Homeostasis Negative Regulation Of Protein Catabolic Process BAT3 Complex Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity Serine-type Carboxypeptidase Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Ankyrin-1 Complex Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport Regulation Of Chaperone-mediated Autophagy Negative Regulation Of ERAD Pathway Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity	Membrane Transmembrane Transport Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Antiporter Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Bile Acid:sodium Symporter Activity Monoatomic Ion Transport Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid
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