TMEM154 and GYPA

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM154	GYPA
Name		transmembrane protein 154	glycophorin A (MNS blood group)
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleoplasm Cytosol Plasma Membrane Membrane Ankyrin-1 Complex
	Molecular Function	Protein Binding	Virus Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	None	Symbiont Entry Into Host Cell
Pathways		None	Cell surface interactions at the vascular wall
GWAS		Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821 ) Hip circumference ( 28552196 ) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507 ) Type 2 diabetes ( 24509480 28869590 29358691 30054458 30297969 30718926 32499647 )	Adult body size ( 32376654 ) Bipolar disorder (body mass index interaction) ( 24322204 ) Blood pressure (smoking interaction) ( 25189868 ) Chronic obstructive pulmonary disease ( 25101718 30804561 ) Diabetic neuropathy in type 2 diabetes ( 33430853 ) Diastolic blood pressure ( 27841878 ) Femoral neck bone mineral density ( 30172743 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Major depressive disorder x sex interaction ( 34099189 ) Malaria ( 31844061 ) Mean corpuscular hemoglobin ( 27863252 ) Mean corpuscular volume ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Platelet count ( 32888494 27863252 ) Plateletcrit ( 32888494 27863252 ) Recurrent major depressive disorder x sex interaction ( 34099189 ) Red blood cell count ( 29403010 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 ) Severe malaria ( 26416757 ) Systolic blood pressure ( 27841878 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) White blood cell count ( 32888494 )
Interacting Genes		11 interacting genes: CLCA4 CTSA CYB561D2 FUNDC2 FXYD6 GET3 GYPA MIP SGTA SLC35A4 SMIM1	24 interacting genes: ANKRD29 CLDN5 CREB3 ELOVL4 ERGIC3 EVA1A FAM209A FFAR2 GOLT1A GPRC5D GPX8 KEAP1 LAPTM5 PDZK1IP1 SAR1A SGTA SGTB SLC10A6 TLCD4 TMBIM6 TMEM14B TMEM154 TMEM237 TMEM31
Entrez ID		201799	2993
HPRD ID		08719	07508
Ensembl ID		ENSG00000170006	ENSG00000170180
Uniprot IDs		Q6P9G4	A0A2R8Y7F9 E9PD10 P02724 Q14419
PDB IDs		Not available	1AFO 2KPE 2KPF 5EH4 5EH6 7UZ3 7V07 7V0K 7V19 8CRQ 8CRR 8CRT 8CS9 8CSL 8CT3 8CTE
GO Terms Enriched among Interactors		Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Membrane Lumenal Side Of Lysosomal Membrane TRC Complex GET Complex Negative Regulation Of Chaperone-mediated Autophagy Ascorbate Homeostasis Negative Regulation Of Protein Catabolic Process BAT3 Complex Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity Serine-type Carboxypeptidase Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Ankyrin-1 Complex Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport Regulation Of Chaperone-mediated Autophagy Negative Regulation Of ERAD Pathway Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity	Membrane TRC Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress Golgi Vesicle Transport Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway COPII Vesicle Coating