TMEM154 and MIP

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM154	MIP
Name		transmembrane protein 154	major intrinsic protein of lens fiber
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane Apical Plasma Membrane Anchoring Junction
	Molecular Function	Protein Binding	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity Channel Activity Cell Adhesion Mediator Activity
	Biological Process	None	Lens Development In Camera-type Eye Water Transport Visual Perception Homotypic Cell-cell Adhesion Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		None	Passive transport by Aquaporins
Drugs		None	B-nonylglucoside
GWAS		Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821 ) Hip circumference ( 28552196 ) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507 ) Type 2 diabetes ( 24509480 28869590 29358691 30054458 30297969 30718926 32499647 )	Axial length ( 24144296 ) Lipoprotein (a) levels ( 33730874 ) Serum metabolite levels ( 33031748 )
Interacting Genes		11 interacting genes: CLCA4 CTSA CYB561D2 FUNDC2 FXYD6 GET3 GYPA MIP SGTA SLC35A4 SMIM1	48 interacting genes: AQP6 AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1
Entrez ID		201799	4284
HPRD ID		08719	01098
Ensembl ID		ENSG00000170006	ENSG00000135517
Uniprot IDs		Q6P9G4	P30301
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Membrane Lumenal Side Of Lysosomal Membrane TRC Complex GET Complex Negative Regulation Of Chaperone-mediated Autophagy Ascorbate Homeostasis Negative Regulation Of Protein Catabolic Process BAT3 Complex Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity Serine-type Carboxypeptidase Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Ankyrin-1 Complex Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport Regulation Of Chaperone-mediated Autophagy Negative Regulation Of ERAD Pathway Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity	Membrane Lens Development In Camera-type Eye Structural Constituent Of Eye Lens Structural Molecule Activity Urea Channel Activity Gap Junction Channel Activity Connexin Complex SNARE Binding Synaptic Vesicle Membrane One-carbon Compound Transport Water Transport Gap Junction Calcium-dependent Protein Binding Organelle Localization By Membrane Tethering Clathrin-sculpted Monoamine Transport Vesicle Membrane Urea Transmembrane Transporter Activity Membrane Docking Camera-type Eye Development Gap Junction-mediated Intercellular Transport Fluid Transport Plasma Membrane Protein Binding Regulation Of Calcium Ion-dependent Exocytosis Chromaffin Granule Membrane Urea Transmembrane Transport Tubulin Complex Assembly Intercellular Transport Amine Transport Urea Transport Modulation Of Chemical Synaptic Transmission Eye Development Positive Regulation Of Catecholamine Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Water Channel Activity Calcium Channel Inhibitor Activity Vesicle Docking Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Dense Core Granule Calcium Ion Sensor Activity Voltage-gated Potassium Channel Complex Sensory Organ Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Glutathione Peroxidase Activity