TMEM154 and CLCA4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM154	CLCA4
Name		transmembrane protein 154	chloride channel accessory 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	None	Proteolysis Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		None	Stimuli-sensing channels
GWAS		Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821 ) Hip circumference ( 28552196 ) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507 ) Type 2 diabetes ( 24509480 28869590 29358691 30054458 30297969 30718926 32499647 )	Fasting glucose ( 34074324 )
Interacting Genes		11 interacting genes: CLCA4 CTSA CYB561D2 FUNDC2 FXYD6 GET3 GYPA MIP SGTA SLC35A4 SMIM1	23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51
Entrez ID		201799	22802
HPRD ID		08719	16719
Ensembl ID		ENSG00000170006	ENSG00000016602
Uniprot IDs		Q6P9G4	Q14CN2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Membrane Lumenal Side Of Lysosomal Membrane TRC Complex GET Complex Negative Regulation Of Chaperone-mediated Autophagy Ascorbate Homeostasis Negative Regulation Of Protein Catabolic Process BAT3 Complex Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity Serine-type Carboxypeptidase Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Ankyrin-1 Complex Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport Regulation Of Chaperone-mediated Autophagy Negative Regulation Of ERAD Pathway Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity	Membrane Transmembrane Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Endoplasmic Reticulum Membrane Endoplasmic Reticulum Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport