UNC13D and RAB27A

Number of citations of the paper that reports this interaction (PMID 14699162)
31

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		UNC13D	RAB27A
Gene Name		unc-13 homolog D (C. elegans)	RAB27A, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Late Endosome Membrane Weibel-Palade Body Recycling Endosome Exocytic Vesicle	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle
	Molecular Function	Protein Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Granuloma Formation Germinal Center Formation Phagocytosis Regulation Of Mast Cell Degranulation Natural Killer Cell Degranulation Positive Regulation Of Exocytosis Defense Response To Virus Positive Regulation Of Regulated Secretory Pathway	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: LMNA RAB27A RAB27B	28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		201294	5873
HPRD ID		10598	04845
Ensembl ID		ENSG00000092929	ENSG00000069974
Uniprot IDs		Q70J99	A2RU94 P51159
PDB IDs
Enriched GO Terms of Interacting Partners?		Multivesicular Body Sorting Pathway Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Cellular Pigmentation Rab Protein Signal Transduction Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Intracellular Protein Transport Pigmentation Protein Secretion Regulation Of Cellular Localization Positive Regulation Of Constitutive Secretory Pathway Complement-dependent Cytotoxicity Sterol Regulatory Element Binding Protein Import Into Nucleus Regulation Of Exocytosis Cellular Protein Localization Establishment Of Vesicle Localization Protein Transport Vesicle Localization Multivesicular Body Organization Cytotoxic T Cell Degranulation Establishment Of Protein Localization Ras Protein Signal Transduction Intracellular Transport Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Exosomal Secretion Protein Localization Establishment Of Organelle Localization Positive Regulation Of Secretion Exocytosis Establishment Of Localization In Cell Natural Killer Cell Degranulation Regulation Of Vesicle-mediated Transport Organelle Localization Protein Targeting Endomembrane System Organization Positive Regulation Of Cell Aging T Cell Mediated Cytotoxicity Cellular Localization Mitotic Nuclear Envelope Reassembly Secretion By Cell Nuclear Envelope Reassembly SREBP Signaling Pathway Response To Sterol Depletion Small GTPase Mediated Signal Transduction Secretion	Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization
Tagcloud ?		actively cargos controversy exocytosis granule granules granulomere gray jinx lacked lapse moved moves periphery platelets premise sort spread spreading subpopulation subpopulations timp2 translocated vamp vamps vefg von willebrand	adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Difference) ?		actively cargos controversy exocytosis granule granules granulomere gray jinx lacked lapse moved moves periphery platelets premise sort spread spreading subpopulation subpopulations timp2 translocated vamp vamps vefg von willebrand	adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Intersection) ?