SPRED2 and ZDHHC17

Number of citations of the paper that reports this interaction (PMID 24705354)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SPRED2	ZDHHC17
Gene Name		sprouty-related, EVH1 domain containing 2	zinc finger, DHHC-type containing 17
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Transport Vesicle Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Integral Component Of Membrane Golgi-associated Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity	Signal Transducer Activity Protein Binding Zinc Ion Binding Magnesium Ion Transmembrane Transporter Activity Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding
	Biological Process	Inactivation Of MAPK Activity Multicellular Organismal Development Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation	Signal Transduction Magnesium Ion Transport Protein Palmitoylation Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967) Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		5 interactors: KIT RHOA SPG21 TOP3B ZDHHC17	191 interactors: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCNE2 CDSN CENPBD1P1 CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM122C FAM135B FAM207A FAM9A FBXO18 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 HBG1 HECTD3 HIST1H2BH HIST1H3H HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT HYPM IFT20 IFT57 INPP5D JMJD7-PLA2G4B KIAA0141 KIAA0226L KIAA0408 KIAA0907 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LGALS9C LIN28A LMAN2L LOC401296 LOC554206 LRRC45 LY6G6C MANF MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF OBFC1 ODF2 OFCC1 OTUD7B OTX2 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SMARCB1 SNAP25 SOX14 SP2 SPRED2 SPRY4 SREBF2 SRSF4 STK25 SUMF2 SYT1 TAF8 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZCCHC6 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9
Entrez ID		200734	23390
HPRD ID		18100	09697
Ensembl ID		ENSG00000198369	ENSG00000186908
Uniprot IDs		B3KPL5 Q7Z698	Q8IUH5
PDB IDs		2JP2	3EU9
Enriched GO Terms of Interacting Partners?		Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Differentiation Skeletal Muscle Satellite Cell Migration Cellular Response To Erythropoietin Mast Cell Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Bone Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apolipoprotein A-I-mediated Signaling Pathway Melanocyte Migration Cleavage Furrow Formation Positive Regulation Of Cell Projection Organization Positive Regulation Of Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Myeloid Progenitor Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Lymphoid Progenitor Cell Differentiation Positive Regulation Of Pseudopodium Assembly Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Neurogenesis Ectopic Germ Cell Programmed Cell Death Immature B Cell Differentiation Cytokine Production Involved In Immune Response Cell Division Megakaryocyte Development Response To Thyroid Hormone Ossification Involved In Bone Maturation Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Bone Maturation Regulation Of Cell Projection Organization Negative Chemotaxis Mitotic Spindle Assembly Lipoprotein Transport Germ Cell Migration	Regulation Of Metabolic Process Transcription, DNA-templated RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Cellular Process Organelle Organization Positive Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Neurotransmitter Uptake Developmental Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Golgi Organization Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Transcription, DNA-templated Chromatin Organization Cellular Component Assembly Regulation Of Gene Silencing Gene Silencing RNA 3'-end Processing Embryo Development Visual Learning Regulation Of Cell Projection Organization Visual Behavior RNA Processing
Tagcloud ?		3g bim bolsters btg3 cdc25a cfue cyclinb1 deployed eaf1 engages epo epor erythroblast erythroblasts gas5 interrogate lyl1 maturing pim1 pim3 presently proerythroblast serpina sf13c socs2 sophisticated tnfr trib3	1b atr atxn3 bcl11b cdkn1a cep290 cxcl5 dmxl1 ensured gfi gnal gnl3l gpr65 gtf2h3 il6st jem knocked lamp1 megakaryocytic mycbp pld1 rac3 rbbp6 reserve rigorous smc3 tmem30 tpr znf292
Tagcloud (Difference) ?		3g bim bolsters btg3 cdc25a cfue cyclinb1 deployed eaf1 engages epo epor erythroblast erythroblasts gas5 interrogate lyl1 maturing pim1 pim3 presently proerythroblast serpina sf13c socs2 sophisticated tnfr trib3	1b atr atxn3 bcl11b cdkn1a cep290 cxcl5 dmxl1 ensured gfi gnal gnl3l gpr65 gtf2h3 il6st jem knocked lamp1 megakaryocytic mycbp pld1 rac3 rbbp6 reserve rigorous smc3 tmem30 tpr znf292
Tagcloud (Intersection) ?