ELF5 and NFE2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ELF5	NFE2
Gene Name		E74-like factor 5 (ets domain transcription factor)	nuclear factor, erythroid 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton PML Body
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Ectoderm Development Cell Proliferation Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Epithelial Cell Differentiation	Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell-cell Signaling Multicellular Organismal Development Blood Coagulation Hemostasis Blood Circulation Negative Regulation Of Bone Mineralization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Transcription, DNA-templated Labyrinthine Layer Blood Vessel Development Positive Regulation Of Peptidyl-lysine Acetylation
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374)	Mean platelet volume ( 22139419)
Protein-Protein Interactions		8 interactors: ACTR2 FRZB NFE2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4	21 interactors: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN WWP1 YAP1
Entrez ID		2001	4778
HPRD ID		05525	09030
Ensembl ID		ENSG00000135374	ENSG00000123405
Uniprot IDs		A6XAE6 A8K443 Q9UKW6	A8K3E0 Q16621
PDB IDs		1WWX	1LVX 2KZ5
Enriched GO Terms of Interacting Partners?			Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Viral Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Oxidative Stress Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Response To Radiation N-terminal Protein Amino Acid Acetylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Modification-dependent Protein Catabolic Process Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Gene Expression
Tagcloud ?		alveolar cited1 collectively conditional cre disruption encodes except foxa1 knockout lineage luminal master mature mechanistically mecs mmtv mutated profound rb1 represses rescued runx runx1 secretory subpopulation subpopulations tf trp53	bear bzip cdna cnc construct designated exert functionally globin heterodimers hmaf homodimerize homodimers k562 kilobase lacks leucine library maf nrf1 nrf2 opposite p45 pair probe recognizable repeat tandem zipper
Tagcloud (Difference) ?		alveolar cited1 collectively conditional cre disruption encodes except foxa1 knockout lineage luminal master mature mechanistically mecs mmtv mutated profound rb1 represses rescued runx runx1 secretory subpopulation subpopulations tf trp53	bear bzip cdna cnc construct designated exert functionally globin heterodimers hmaf homodimerize homodimers k562 kilobase lacks leucine library maf nrf1 nrf2 opposite p45 pair probe recognizable repeat tandem zipper
Tagcloud (Intersection) ?