ELF5 and NFE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ELF5	NFE2
Description		E74 like ETS transcription factor 5	nuclear factor, erythroid 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding WW Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ectodermal Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ectoderm Development Cell Differentiation Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Mammary Gland Epithelial Cell Differentiation Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development	Nucleosome Disassembly Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Hemostasis Positive Regulation Of DNA-templated Transcription Integrated Stress Response Signaling
Pathways		Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Metabolite levels ( 23823483)	Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 22139419 24026423) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Platelet count ( 27863252 29403010 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: ACTR2 CRBN FRZB GLRX2 NFE2 NFE2L2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4	22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN UBE2I WWP1 YAP1
Entrez ID		2001	4778
HPRD ID		05525	09030
Ensembl ID		ENSG00000135374	ENSG00000123405
Uniprot IDs		A0A087X1W9 A8K443 Q9UKW6	A8K3E0 Q16621
PDB IDs		1WWX	2KZ5
Enriched GO Terms of Interacting Partners?		Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Cellular Component Organization Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Integrated Stress Response Signaling Nucleus Positive Regulation Of Cellular Component Organization Cell Redox Homeostasis Regulation Of Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Regulation Of DNA Repair Site Of DNA Damage Negative Regulation Of Hepatocyte Differentiation Positive Regulation Of Glutathione Biosynthetic Process Regulation Of D-glucose Import Arsenate Reductase (glutaredoxin) Activity Histone H3K56 Deacetylase Activity, NAD-dependent Positive Regulation Of Fat Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Differentiation Regulation Of Glutathione Biosynthetic Process Regulation Of D-glucose Transmembrane Transport Aflatoxin Catabolic Process Glutathione Disulfide Oxidoreductase Activity Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism Chromosome, Subtelomeric Region Histone H3K9 Deacetylase Activity, NAD-dependent NAD-dependent Protein Depalmitoylase Activity Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein Demyristoylase Activity Nuclear Proteasome Complex Positive Regulation Of Cell Projection Organization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Double-strand Break Repair Site Of Double-strand Break Cellular Response To Stress Regulation Of RNA Metabolic Process Meiotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Protein Localization To Chromatin Negative Regulation Of Autophagosome Maturation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Proteasomal Ubiquitin-independent Protein Catabolic Process	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Chromatin Post-translational Protein Modification Positive Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels Response To Radiation Response To UV Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription N-terminal Peptidyl-lysine Acetylation Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxidative Stress Cellular Response To Stress DNA-binding Transcription Factor Activity Integrated Stress Response Signaling Rhythmic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Chemical Stress Positive Regulation Of Macromolecule Biosynthetic Process Response To Nutrient Levels Positive Regulation Of Biosynthetic Process Protein Monoubiquitination
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?