ELF5 and SIRT6

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ELF5	SIRT6
Gene Name		E74-like factor 5 (ets domain transcription factor)	sirtuin 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Nucleolus Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription	Chromatin Binding NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Ectoderm Development Cell Proliferation Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Epithelial Cell Differentiation	Protein ADP-ribosylation Regulation Of Double-strand Break Repair Via Homologous Recombination Histone Deacetylation Histone H3-K9 Modification Histone H3 Deacetylation
Pathways
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374)
Protein-Protein Interactions		8 interactors: ACTR2 FRZB NFE2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4	10 interactors: AKT1 CCNDBP1 CHD3 ELF5 FAF1 RELA SKP2 STUB1 UBE2D1 VIM
Entrez ID		2001	51548
HPRD ID		05525	12093
Ensembl ID		ENSG00000135374	ENSG00000077463
Uniprot IDs		A6XAE6 A8K443 Q9UKW6	B4DDV3 Q8N6T7
PDB IDs		1WWX	3K35 3PKI 3PKJ 3ZG6
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Mammary Gland Epithelial Cell Differentiation Modification-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Growth Factor Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Catabolic Process Cell Cycle Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Proteolysis Positive Regulation Of Proteolysis Cellular Macromolecule Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Execution Phase Of Apoptosis Glycogen Cell Differentiation Involved In Embryonic Placenta Development Acetaldehyde Metabolic Process Catabolic Process Positive Regulation Of Ligase Activity Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor 4 Signaling Pathway Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Component Organization Epithelium Development Negative Regulation Of Signal Transduction Cellular Response To Hypoxia Mammary Gland Epithelium Development Cellular Response To Decreased Oxygen Levels Response To Extracellular Stimulus
Tagcloud ?		alveolar cited1 collectively conditional cre disruption encodes except foxa1 knockout lineage luminal master mature mechanistically mecs mmtv mutated profound rb1 represses rescued runx runx1 secretory subpopulation subpopulations tf trp53	accompanying bend cat catalase cse cystathionine cytoprotection dehydrogenase dependently deprivation deteriorated dismutase endothelial gaseous h2s lactate lyase na2s ogd propargylglycine protected protective reperfusion simulated sirtuin sod sulfide superoxide transmitter
Tagcloud (Difference) ?		alveolar cited1 collectively conditional cre disruption encodes except foxa1 knockout lineage luminal master mature mechanistically mecs mmtv mutated profound rb1 represses rescued runx runx1 secretory subpopulation subpopulations tf trp53	accompanying bend cat catalase cse cystathionine cytoprotection dehydrogenase dependently deprivation deteriorated dismutase endothelial gaseous h2s lactate lyase na2s ogd propargylglycine protected protective reperfusion simulated sirtuin sod sulfide superoxide transmitter
Tagcloud (Intersection) ?