ELF5 and NRIP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ELF5	NRIP2
Description		E74 like ETS transcription factor 5	nuclear receptor interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Aspartic-type Endopeptidase Activity Protein Binding
	Biological Process	Ectodermal Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ectoderm Development Cell Differentiation Somatic Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Mammary Gland Epithelial Cell Differentiation Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Notch Signaling Pathway
Pathways		Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: ACTR2 CRBN FRZB GLRX2 NFE2 NFE2L2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4	8 interacting genes: AKT1 BANP CCNG2 ELF5 HDAC7 RARA RORB ZNF76
Entrez ID		2001	83714
HPRD ID		05525	14839
Ensembl ID		ENSG00000135374	ENSG00000053702
Uniprot IDs		A0A087X1W9 A8K443 Q9UKW6	Q9BQI9
PDB IDs		1WWX
Enriched GO Terms of Interacting Partners?		Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Cellular Component Organization Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Integrated Stress Response Signaling Nucleus Positive Regulation Of Cellular Component Organization Cell Redox Homeostasis Regulation Of Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Regulation Of DNA Repair Site Of DNA Damage Negative Regulation Of Hepatocyte Differentiation Positive Regulation Of Glutathione Biosynthetic Process Regulation Of D-glucose Import Arsenate Reductase (glutaredoxin) Activity Histone H3K56 Deacetylase Activity, NAD-dependent Positive Regulation Of Fat Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Differentiation Regulation Of Glutathione Biosynthetic Process Regulation Of D-glucose Transmembrane Transport Aflatoxin Catabolic Process Glutathione Disulfide Oxidoreductase Activity Histone H3K9 Deacetylase Activity, Hydrolytic Mechanism Chromosome, Subtelomeric Region Histone H3K9 Deacetylase Activity, NAD-dependent NAD-dependent Protein Depalmitoylase Activity Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein Demyristoylase Activity Nuclear Proteasome Complex Positive Regulation Of Cell Projection Organization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Double-strand Break Repair Site Of Double-strand Break Cellular Response To Stress Regulation Of RNA Metabolic Process Meiotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Protein Localization To Chromatin Negative Regulation Of Autophagosome Maturation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Proteasomal Ubiquitin-independent Protein Catabolic Process	Mammary Gland Epithelial Cell Differentiation Sequence-specific DNA Binding 14-3-3 Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Regulation Of Myelination Negative Regulation Of Cell Differentiation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of RNA Biosynthetic Process Striated Muscle Cell Differentiation Regulation Of Cell Differentiation Nucleus Regulation Of TRNA Methylation Positive Regulation Of DNA-templated Transcription Sertoli Cell Fate Commitment Nuclear Receptor Activity Cellular Response To Retinoic Acid Negative Regulation Of Osteoblast Differentiation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Localization To Lysosome DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Ectodermal Cell Fate Commitment DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Response To Lipid Response To Retinoic Acid Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of RNA Metabolic Process Response To Insulin-like Growth Factor Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Muscle Cell Differentiation Positive Regulation Of Endothelial Cell Migration Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity DNA Binding Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Trachea Cartilage Development
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