EGR2 and BPGM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EGR2	BPGM
Description		early growth response 2	bisphosphoglycerate mutase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Cytosol Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Ligase Activity Sequence-specific Double-stranded DNA Binding	Catalytic Activity Bisphosphoglycerate Mutase Activity Phosphoglycerate Mutase Activity Protein Binding Hydrolase Activity Isomerase Activity Intramolecular Phosphotransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Brain Development Peripheral Nervous System Development Rhythmic Behavior Motor Neuron Axon Guidance Gene Expression Schwann Cell Differentiation Positive Regulation Of Schwann Cell Differentiation Protein Sumoylation Rhombomere 3 Development Facial Nerve Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Structural Organization Rhombomere 5 Formation Regulation Of Ossification Positive Regulation Of Myelination Brain Segmentation Aorta Development Skeletal Muscle Cell Differentiation Myelination Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Carbohydrate Metabolic Process Glycolytic Process Nucleoside Phosphate Metabolic Process Respiratory Gaseous Exchange By Respiratory System Oxygen Transport Cellular Response To Stress Defense Response To Protozoan Erythrocyte Development Establishment Of Blood-brain Barrier Neuroinflammatory Response Carbohydrate Derivative Catabolic Process
Pathways		Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination	Glycolysis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Adventurousness ( 30643258) Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Ewing sarcoma ( 22327514) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Monocyte percentage of white cells ( 32888494) Selective IgA deficiency ( 27723758) Temperament ( 22832960) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Vogt-Koyanagi-Harada syndrome ( 25108386)	Blood protein levels ( 30072576)
Interacting Genes		21 interacting genes: ACP5 BPGM DNMT3L GOLGA2 HCFC1 JPT2 MCRS1 MED31 NAB2 NDUFS2 NFATC1 PDE4DIP RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WEE2-AS1 WWP2	9 interacting genes: AKT1 ATF6 ATP4B CEL EGR2 EHD2 GAPDH GRB2 NEK3
Entrez ID		1959	669
HPRD ID		00551	01961
Ensembl ID		ENSG00000122877	ENSG00000172331
Uniprot IDs		A0A8I5KYI5 P11161	A0A024R782 P07738
PDB IDs			1T8P 2A9J 2F90 2H4X 2H4Z 2H52 2HHJ 3NFY 7N3R 7N3S 7THI 8X2S
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process NSL Complex Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Glial Cell Differentiation Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex Positive Regulation Of RNA Biosynthetic Process MLL1 Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Development Negative Regulation Of Myoblast Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Superoxide Anion Generation Positive Regulation Of RNA Metabolic Process SUMO Conjugating Enzyme Activity Citrate-L-glutamate Ligase Activity N-acetyl-L-aspartate-L-glutamate Ligase Activity Oligodendrocyte Differentiation DNA-binding Transcription Factor Binding Regulation Of Gene Expression Centrosome Cycle	Insulin-like Growth Factor Receptor Signaling Pathway ER-nucleus Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Myelination Regulation Of TRNA Methylation Rhombomere 5 Structural Organization Rhombomere 3 Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum ERBB Signaling Pathway Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of Response To Endoplasmic Reticulum Stress TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Regulation Of Autophagy Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Insulin Receptor Signaling Pathway Identical Protein Binding P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Acetylesterase Activity Rhombomere 3 Development Positive Regulation Of Schwann Cell Differentiation Brain Segmentation Myelination Axon Ensheathment Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Peptidyl-cysteine S-nitrosylase Activity Grb2-EGFR Complex Plasma Membrane Organization Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Glucose Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Sterol Ester Esterase Activity Regulation Of Schwann Cell Differentiation Peptidyl-cysteine S-nitrosylation GAIT Complex
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