EGR2 and NDUFS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EGR2	NDUFS2
Gene Name		early growth response 2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ligase Activity Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding HMG Box Domain Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Carrier Activity Metal Ion Binding Quinone Binding NAD Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Protein Export From Nucleus Brain Development Peripheral Nervous System Development Learning Or Memory Rhythmic Behavior Motor Neuron Axon Guidance Schwann Cell Differentiation Protein Sumoylation Facial Nerve Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Regulation Of Ossification Response To Insulin Brain Segmentation Skeletal Muscle Cell Differentiation Myelination Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neuronal Synaptic Plasticity Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Transcriptional regulation of white adipocyte differentiation	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS		Atopic dermatitis ( 23042114) Ewing sarcoma ( 22327514) Temperament ( 22832960)
Protein-Protein Interactions		16 interactors: ACP5 BPGM HCFC1 HN1L MED31 NAB2 NDUFS2 NFATC1 RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WWP2	5 interactors: APP CENPU EGR2 HMOX2 TNFRSF14
Entrez ID		1959	4720
HPRD ID		00551	04285
Ensembl ID		ENSG00000122877	ENSG00000158864
Uniprot IDs		P11161	B7Z792 O75306
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Enteric Nervous System Development Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Peripheral Nervous System Development Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Development Heterocycle Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Mesenchymal Cell Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Glial Cell Differentiation Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Mesenchyme Development Viral Process Gene Expression Nucleobase-containing Compound Metabolic Process Autonomic Nervous System Development Cellular Macromolecule Biosynthetic Process Gliogenesis Neural Crest Cell Migration Regulation Of Metabolic Process Stem Cell Development Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gliogenesis Metabolic Process Positive Regulation Of SUMO Transferase Activity Neural Crest Cell Development Stem Cell Differentiation Oligodendrocyte Differentiation Neural Crest Cell Differentiation Retinal Rod Cell Differentiation Negative Regulation Of Superoxide Anion Generation Release From Viral Latency Regulation Of Gliogenesis Renal Vesicle Induction	Rhombomere 5 Formation Rhombomere 3 Formation Transition Metal Ion Homeostasis Rhombomere 3 Morphogenesis Synaptic Growth At Neuromuscular Junction Brain Segmentation Collateral Sprouting In Absence Of Injury Heme Oxidation Regulation Of Peptidyl-tyrosine Phosphorylation Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Cytokine Secretion Involved In Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Rhombomere Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Locomotion Cognition Negative Regulation Of Alpha-beta T Cell Proliferation Heme Catabolic Process Neuron Remodeling Rhombomere Development Facial Nerve Structural Organization Regulation Of Cytokine Secretion Involved In Immune Response Axon Guidance Facial Nerve Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Response To Oxidative Stress Cellular Cation Homeostasis Cellular Ion Homeostasis Positive Regulation Of T Cell Migration Single-organism Behavior Metal Ion Homeostasis Cellular Copper Ion Homeostasis Response To External Stimulus Rhythmic Behavior Regulation Of T Cell Migration Parasympathetic Nervous System Development Regulation Of Cellular Ketone Metabolic Process Anatomical Structure Arrangement Copper Ion Homeostasis Suckling Behavior Axonogenesis Cellular Chemical Homeostasis Negative Regulation Of Alpha-beta T Cell Activation Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		1beta attraction ccl2 ccl7 cd40 chemokines csf1 cxcl10 dark dendrites elongation enforced exert homer1a ht22 microglia mononuclear movement nrem phagocytes profoundly sleep somnogeneic stimulate synapses tnf vicinity wake wakefulness	accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf3 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Difference) ?		1beta attraction ccl2 ccl7 cd40 chemokines csf1 cxcl10 dark dendrites elongation enforced exert homer1a ht22 microglia mononuclear movement nrem phagocytes profoundly sleep somnogeneic stimulate synapses tnf vicinity wake wakefulness	accounting agf3l2 assembly c20orf7 c8orf38 chase confirming docks holoenzyme immunoprecipitated knock knocked labeling module mtdna nadh nd1 ndufa9 ndufaf3 ndufaf4 nucleating oxidoreductase proteolysis pulse redundant stabilizes ubiquinone
Tagcloud (Intersection) ?