CELSR3 and SPTBN2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		CELSR3	SPTBN2
Description		cadherin EGF LAG seven-pass G-type receptor 3	spectrin beta, non-erythrocytic 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Membrane	Extracellular Space Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Membrane Apical Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranodal Junction Cell Projection Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Synapse Structural Constituent Of Postsynapse
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axonogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Cell-cell Adhesion Mediated By Cadherin Wnt Signaling Pathway, Planar Cell Polarity Pathway	Synapse Assembly Vesicle-mediated Transport Cerebellar Purkinje Cell Layer Morphogenesis Actin Cytoskeleton Organization Adult Behavior Multicellular Organism Growth Actin Filament Capping Regulation Of Postsynaptic Specialization Assembly Postsynapse Organization
Pathways			MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mental health study participation (provided email address) ( 31263887) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)	Bipolar disorder ( 21926972 28115744 31043756) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder (MTAG) ( 33479212)
Interacting Genes		14 interacting genes: CLK1 CLUH DSCR9 DST IFT140 REST SCAPER SGSM2 SPTBN2 SPTBN4 SWAP70 TRIP12 TSPYL4 UACA	11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 PCNT SPTA1 UNC13B
Entrez ID		1951	6712
HPRD ID		09179	05404
Ensembl ID		ENSG00000008300	ENSG00000173898
Uniprot IDs		Q9NYQ7	A0A087WYQ1 O15020
PDB IDs			1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Spectrin Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Protein-containing Complex Disassembly Actin Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Actin Filament Capping Cell Cortex Cell Junction Organization Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Amniotic Stem Cell Differentiation Negative Regulation Of Actin Filament Polymerization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Cytoskeleton Cortical Actin Cytoskeleton H Zone Negative Regulation Of Mesenchymal Stem Cell Differentiation Synapse Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Cerebellar Purkinje Cell Layer Morphogenesis Structural Constituent Of Postsynapse Heterochromatin Boundary Formation Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Chromatin Remodeling	Cytoskeleton Structural Constituent Of Cytoskeleton Regulation Of Protein-containing Complex Disassembly Axon Lamellipodium Cortical Cytoskeleton Adherens Junction Cytoskeleton Organization Kinetochore Cell Cortex Microtubule Associated Complex Actin Cytoskeleton Cell Projection Morphogenesis Neuron Projection Morphogenesis Tau Protein Binding Regulation Of Organelle Organization Cell Projection Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Microtubule Cytoskeleton Positive Regulation Of Mini Excitatory Postsynaptic Potential Centrosome Positive Regulation Of Synaptic Vesicle Priming Homeostatic Process Cytosol Negative Regulation Of Protein-containing Complex Disassembly Actin Filament Actin Filament-based Process Regulation Of Transport Regulation Of Mitotic Metaphase/anaphase Transition Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Transporter Regulator Activity Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Intercellular Bridge Beta2-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Protein Depolymerization Regulation Of Supramolecular Fiber Organization Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Microtubule Organizing Center Dense Core Granule Priming
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