CELSR3 and SCAPER

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		CELSR3	SCAPER
Description		cadherin EGF LAG seven-pass G-type receptor 3	S-phase cyclin A associated protein in the ER
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Nuclear Speck Sperm Head Ooplasm
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axonogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Cell-cell Adhesion Mediated By Cadherin Wnt Signaling Pathway, Planar Cell Polarity Pathway	Ovarian Follicle Development Antral Ovarian Follicle Growth Spermatogenesis Retina Development In Camera-type Eye Seminiferous Tubule Development
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mental health study participation (provided email address) ( 31263887) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)	Appendicular lean mass ( 33097823) Bitter alcoholic beverage consumption ( 31046077) Clostridioides difficle infection in antibiotics-users ( 33841421) Estimated glomerular filtration rate ( 31152163) Late-onset Alzheimer's disease ( 27770636) Neonatal white matter microstructure ( 33009551) Neurociticism ( 29500382) Recalcitrant atopic dermatitis ( 25935106) Urate levels ( 31578528)
Interacting Genes		14 interacting genes: CLK1 CLUH DSCR9 DST IFT140 REST SCAPER SGSM2 SPTBN2 SPTBN4 SWAP70 TRIP12 TSPYL4 UACA	4 interacting genes: APPL1 CALM1 CELSR3 MEGF10
Entrez ID		1951	49855
HPRD ID		09179	11704
Ensembl ID		ENSG00000008300	ENSG00000140386
Uniprot IDs		Q9NYQ7	Q9BY12
PDB IDs			8BPO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Depolymerization Regulation Of Actin Filament Depolymerization Spectrin Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein Depolymerization Regulation Of Protein-containing Complex Disassembly Actin Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Actin Filament Capping Cell Cortex Cell Junction Organization Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Amniotic Stem Cell Differentiation Negative Regulation Of Actin Filament Polymerization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Cytoskeleton Cortical Actin Cytoskeleton H Zone Negative Regulation Of Mesenchymal Stem Cell Differentiation Synapse Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Cerebellar Purkinje Cell Layer Morphogenesis Structural Constituent Of Postsynapse Heterochromatin Boundary Formation Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Chromatin Remodeling	Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cell Projection Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Positive Regulation Of Pinocytosis Positive Regulation Of Macropinocytosis Macropinosome Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adiponectin-activated Signaling Pathway Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Complement Component C1q Complex Binding Myoblast Development Skeletal Muscle Satellite Cell Activation Positive Regulation Of Melanin Biosynthetic Process Regulation Of Voltage-gated Calcium Channel Activity Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Melanin Biosynthetic Process Early Phagosome Cellular Response To Hepatocyte Growth Factor Stimulus Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Skeletal Muscle Cell Proliferation Phagocytosis, Recognition Myoblast Migration Positive Regulation Of Myoblast Proliferation Negative Regulation Of Transport Regulation Of Cell Communication By Electrical Coupling Response To Hepatocyte Growth Factor Endocytosis Protein Phosphatase Activator Activity Calyx Of Held Plasma Membrane Cell-cell Adhesion
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