PHC1 and PCGF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PHC1	PCGF3
Description		polyhomeotic homolog 1	polycomb group ring finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	X Chromosome Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor	Regulation Of Transcription By RNA Polymerase II Random Inactivation Of X Chromosome
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 22443383) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Schizophrenia ( 33169155) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 30297969 32499647) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)
Interacting Genes		25 interacting genes: BMI1 CRYAA FAM9A GMNN HSPA8 PCGF3 PHC2 PIAS2 PPIL3 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7	11 interacting genes: BMI1 DZIP3 HNRNPK PHC1 PHC2 RING1 TRIM55 TRIM63 TRIM9 UBE2C UBE2D3
Entrez ID		1911	10336
HPRD ID		16009	11515
Ensembl ID		ENSG00000111752	ENSG00000185619
Uniprot IDs		P78364 Q6GMQ3	B3KQ06 B3KWT8 B4DTN5 Q3KNV8
PDB IDs		2L8E
Enriched GO Terms of Interacting Partners?		PRC1 Complex Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription PcG Protein Complex Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process PML Body Nuclear Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Regulation Of Macromolecule Metabolic Process Transcription Factor Binding Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Transcription Corepressor Activity Histone H2AK119 Ubiquitin Ligase Activity Post-translational Protein Modification Small Protein Activating Enzyme Binding Nuclear Speck Nucleolus Epigenetic Regulation Of Gene Expression PTW/PP1 Phosphatase Complex Sex Chromatin PML Body Organization Regulation Of Primary Metabolic Process Protein Modification Process Heterochromatin Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Intracellular Transport Histone Binding Chromatin Organization Regulation Of Protein Stability Zinc Ion Binding Protein Tag Activity Chromatin Remodeling Nuclear Body Organization Protein Metabolic Process	PRC1 Complex Ubiquitin Protein Ligase Activity PcG Protein Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Zinc Ion Binding Sex Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-protein Transferase Activator Activity Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Chromatin Binding Ubiquitin Conjugating Enzyme Activity Protein K11-linked Ubiquitination Metal Ion Binding Heterochromatin Negative Regulation Of Metabolic Process Chromatin Remodeling Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-1 Regulation Of Adaxial/abaxial Pattern Formation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Biosynthetic Process Nuclear Body Chromatin Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Positive Regulation Of Protein Ubiquitination Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Exit From Mitosis Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Primary Metabolic Process Nucleus Response To Glucocorticoid Proteasomal Protein Catabolic Process
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