PHC1 and PPIL3

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PHC1	PPIL3
Description		polyhomeotic homolog 1	peptidylprolyl isomerase like 3
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GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity
	Biological Process	Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		25 interacting genes: BMI1 CRYAA FAM9A GMNN HSPA8 PCGF3 PHC2 PIAS2 PPIL3 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7	10 interacting genes: CENATAC DMRTB1 PCBP1 PHC1 RPS13 SHARPIN SLU7 TAB2 TAB3 YTHDF1
Entrez ID		1911	53938
HPRD ID		16009	15163
Ensembl ID		ENSG00000111752	ENSG00000240344
Uniprot IDs		P78364 Q6GMQ3	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs		2L8E	1XYH 2OJU 2OK3 8C6J
Enriched GO Terms of Interacting Partners?		PRC1 Complex Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription PcG Protein Complex Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process PML Body Nuclear Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Regulation Of Macromolecule Metabolic Process Transcription Factor Binding Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Transcription Corepressor Activity Histone H2AK119 Ubiquitin Ligase Activity Post-translational Protein Modification Small Protein Activating Enzyme Binding Nuclear Speck Nucleolus Epigenetic Regulation Of Gene Expression PTW/PP1 Phosphatase Complex Sex Chromatin PML Body Organization Regulation Of Primary Metabolic Process Protein Modification Process Heterochromatin Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Intracellular Transport Histone Binding Chromatin Organization Regulation Of Protein Stability Zinc Ion Binding Protein Tag Activity Chromatin Remodeling Nuclear Body Organization Protein Metabolic Process
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