PHC1 and SFMBT1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		PHC1	SFMBT1
Description		polyhomeotic homolog 1	Scm like with four mbt domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding
	Biological Process	Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Cellular Response To Retinoic Acid Cellular Response To Leukemia Inhibitory Factor	Chromatin Organization Regulation Of DNA-templated Transcription Spermatogenesis Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Muscle Organ Development
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 29124443) General cognitive ability ( 29844566) Gout ( 33832965 31578528) Haemorrhoidal disease ( 33888516) Hand grip strength ( 29691431) Height ( 28552196 31562340 31217584) Hip circumference ( 28552196) Hyperuricemia ( 29124443) Intelligence (MTAG) ( 29326435) Mental health study participation (completed survey) ( 31263887) Multiple sclerosis ( 31604244) Schizophrenia ( 28991256 23974872) Serum uric acid levels ( 30993211 29403010 29124443) Type 2 diabetes (age of onset) ( 28060188) Urate levels ( 23263486 31985003 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		25 interacting genes: BMI1 CRYAA FAM9A GMNN HSPA8 PCGF3 PHC2 PIAS2 PPIL3 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7	12 interacting genes: ACP1 ATOSB CLNK HOXB9 PHC1 PHC2 PSMA1 SCMH1 SPANXN2 SRPK1 WWP2 ZCCHC10
Entrez ID		1911	51460
HPRD ID		16009	09539
Ensembl ID		ENSG00000111752	ENSG00000163935
Uniprot IDs		P78364 Q6GMQ3	Q9UHJ3
PDB IDs		2L8E
Enriched GO Terms of Interacting Partners?		PRC1 Complex Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription PcG Protein Complex Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process PML Body Nuclear Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Regulation Of Macromolecule Metabolic Process Transcription Factor Binding Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Transcription Corepressor Activity Histone H2AK119 Ubiquitin Ligase Activity Post-translational Protein Modification Small Protein Activating Enzyme Binding Nuclear Speck Nucleolus Epigenetic Regulation Of Gene Expression PTW/PP1 Phosphatase Complex Sex Chromatin PML Body Organization Regulation Of Primary Metabolic Process Protein Modification Process Heterochromatin Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Intracellular Transport Histone Binding Chromatin Organization Regulation Of Protein Stability Zinc Ion Binding Protein Tag Activity Chromatin Remodeling Nuclear Body Organization Protein Metabolic Process	PcG Protein Complex PRC1 Complex Histone Binding
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