PHC1 and SP100

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PHC1	SP100
Gene Name		polyhomeotic homolog 1 (Drosophila)	SP100 nuclear antigen
Image
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Mre11 Complex Nuclear Periphery
	Molecular Function	DNA Binding Chromatin Binding Zinc Ion Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Chromo Shadow Domain Binding
	Biological Process	Multicellular Organismal Development Histone Ubiquitination Cellular Response To Retinoic Acid	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Chromatin Remodeling Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Endothelial Cell Migration Viral Process Cytokine-mediated Signaling Pathway Response To Retinoic Acid Negative Regulation Of Viral Transcription Response To Cytokine Response To Type I Interferon Response To Interferon-gamma Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Export From Nucleus Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Component Movement Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: BMI1 GMNN HSPA8 PCGF2 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 SCMH1 SFMBT1 SIAH1 SP100 SUMO1 SUMO1P1 UBE2I ZCCHC7	38 interactors: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREM DNMT3A DYRK2 ETS1 GIPC2 HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML RANBP2 RBM39 RTP5 SAE1 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBA2 UBE2I USPL1 ZC2HC1A
Entrez ID		1911	6672
HPRD ID		16009	06844
Ensembl ID		ENSG00000111752	ENSG00000067066
Uniprot IDs		B4DF21 J3KQH6 P78364 Q6GMQ3 Q6N083	E7EUA7 P23497 Q6ZMK3
PDB IDs		2L8E	1H5P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Metabolic Process Chromatin Modification Chromatin Organization Regulation Of Metabolic Process Anterior/posterior Pattern Specification Peptidyl-lysine Modification Protein Sumoylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Ubiquitination Histone Ubiquitination Regulation Of RNA Metabolic Process Chromosome Organization Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Cellular Protein Modification Process Pattern Specification Process Cellular Protein Metabolic Process Developmental Process Regulation Of Signal Transduction Histone H2A Monoubiquitination Histone H2A Ubiquitination Regulation Of Signaling Organelle Organization RNA Metabolic Process Histone Monoubiquitination Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Protein Metabolic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cell Division Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process	Protein Sumoylation PML Body Organization Regulation Of Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Post-translational Protein Modification Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleus Organization Regulation Of Transcription, DNA-templated Peptidyl-amino Acid Modification Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Cellular Process SMT3-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Proteolysis RNA-dependent DNA Replication Positive Regulation Of Cellular Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Chromosome Organization Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Protein Desumoylation Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Telomere Capping Chromatin Modification Positive Regulation Of Cellular Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase
Tagcloud ?		bmi1a bmi1b cbx2 cbx4 cbx6a cbx6b cbx7a cbx7b cbx8a cbx8b combs enormous orthologs pcgf1 pcgf5a pcgf5b pcgf6 phc2a phc2b phc3 polyhomeotic prc1 psc ring1 rnf2 sce syntenies syntheses trimethylates	aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg
Tagcloud (Difference) ?		bmi1a bmi1b cbx2 cbx4 cbx6a cbx6b cbx7a cbx7b cbx8a cbx8b combs enormous orthologs pcgf1 pcgf5a pcgf5b pcgf6 phc2a phc2b phc3 polyhomeotic prc1 psc ring1 rnf2 sce syntenies syntheses trimethylates	aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg
Tagcloud (Intersection) ?