MPDZ and CSPG4

Number of citations of the paper that reports this interaction (PubMedID 10967549)
61

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MPDZ	CSPG4
Description		multiple PDZ domain crumbs cell polarity complex component	chondroitin sulfate proteoglycan 4
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Bicellular Tight Junction Postsynaptic Density Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cell Projection Neuron Projection Apical Part Of Cell Synapse Anchoring Junction	Ruffle Extracellular Region Nucleoplasm Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Extracellular Matrix Lamellipodium Membrane Cell Projection Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Coreceptor Activity Protein Kinase Binding
	Biological Process	Tight Junction Assembly	Angiogenesis Substrate-dependent Cell Migration Signal Transduction Glial Cell Migration Cell Differentiation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Ruffle Assembly
Pathways			Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Corneal hysteresis ( 30894546 32716492) Corneal structure ( 23291589) Heel bone mineral density ( 28869591 30598549) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)	Estimated glomerular filtration rate ( 31015462) Hip index ( 34021172) Intraocular pressure ( 29617998) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		19 interacting genes: ABCA1 CAMK2A CCDC88C CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PELI2 PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2 VANGL2	9 interacting genes: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2
Entrez ID		8777	1464
HPRD ID		09155	03105
Ensembl ID		ENSG00000107186	ENSG00000173546
Uniprot IDs		O75970	Q6UVK1
PDB IDs		2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1	7ML7 7N8X 7N9Y
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Plasma Membrane Cell-cell Junction Regulation Of Bicellular Tight Junction Assembly PDZ Domain Binding Regulation Of Cell Communication Regulation Of Signaling Maintenance Of Blood-brain Barrier Tight Junction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Learning Visual Learning Regulation Of Neuronal Synaptic Plasticity Visual Behavior Regulation Of MAPK Cascade Positive Regulation Of Bicellular Tight Junction Assembly Lateral Plasma Membrane Cell Junction Signal Transduction Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Endothelial Intestinal Barrier G Protein-coupled Receptor Signaling Pathway Associative Learning Response To Alcohol Positive Regulation Of Signal Transduction Regulation Of Establishment Of Endothelial Barrier Learning Or Memory Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Response To Ethanol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Ruffle Organization Cognition Bicellular Tight Junction Regulation Of Long-term Neuronal Synaptic Plasticity Phosphatidylinositol-3,4-bisphosphate Binding Face Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress	Endothelin Receptor Signaling Pathway Integrin-mediated Signaling Pathway Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Anchoring Junction Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Localization To Synapse Establishment Of Protein Localization To Plasma Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Localization To Synapse Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels ERBB Signaling Pathway Endocytic Recycling Protein Localization To Cell Junction Apical Part Of Cell Establishment Of Cell Polarity GBD Domain Binding Storage Vacuole Grb2-EGFR Complex Activation Of Immune Response Focal Adhesion Complement Component C1q Complex Vertebrate Eye-specific Patterning Cell Junction Organization Protein Kinase Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Dendrite Cytoophidium Cell Surface Receptor Signaling Pathway Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Apolipoprotein A-I Receptor Binding Vesicle-mediated Transport Neuropilin Signaling Pathway Plasma Membrane Protein Tyrosine Kinase Activity Vesicle-mediated Transport To The Plasma Membrane IgM Binding
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