MPDZ and CSPG4

Number of citations of the paper that reports this interaction (PMID 10967549)
16

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MPDZ	CSPG4
Gene Name		multiple PDZ domain protein	chondroitin sulfate proteoglycan 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cytoplasmic Vesicle Schmidt-Lanterman Incisure Postsynaptic Membrane	Extracellular Region Golgi Lumen Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Apical Plasma Membrane Lamellipodium Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding	Signal Transducer Activity Protein Kinase Binding
	Biological Process	Cell Adhesion Viral Process Myelination	Activation Of MAPK Activity Angiogenesis Carbohydrate Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Glial Cell Migration Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Intracellular Signal Transduction Small Molecule Metabolic Process Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Corneal structure ( 23291589)
Protein-Protein Interactions		13 interactors: ABCA1 CAMK2A CLDN1 CLDN5 CSPG4 DRD3 F11R HTR2C KIT PLEKHA1 PLEKHA2 RNF5 SYNGAP1	9 interactors: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2
Entrez ID		8777	1464
HPRD ID		09155	03105
Ensembl ID		ENSG00000107186	ENSG00000173546
Uniprot IDs		F5H1U9 O75970	Q6UVK1
PDB IDs		2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Signaling Visual Learning Visual Behavior Associative Learning Regulation Of Synaptic Transmission Regulation Of Signal Transduction Learning Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Radiation Single-organism Behavior Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Permeability Response To Abiotic Stimulus Negative Regulation Of Protein Kinase B Signaling Behavior Regulation Of MAPK Cascade Cellular Response To Stimulus Signal Transduction Learning Or Memory Cognition Negative Regulation Of Cell Differentiation Regulation Of Lipid Metabolic Process Homeostatic Process Rhythmic Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Signaling Response To Light Stimulus Cell Communication Membrane Organization Chemical Homeostasis Positive Regulation Of Metabolic Process Cellular Localization Response To Stress Regulation Of Cell Differentiation Regulation Of CAMP Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sodium:proton Antiporter Activity Regulation Of Corticotropin-releasing Hormone Secretion Gastric Emptying Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway	Vascular Endothelial Growth Factor Receptor Signaling Pathway Establishment Of Nucleus Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nucleus Localization Peptidyl-tyrosine Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphatidylinositol 3-kinase Activity Cell Migration Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lipid Kinase Activity Cell Motility Positive Regulation Of Immune System Process Cell-cell Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Blood Coagulation Hemostasis Immune System Process Immune Response-regulating Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Positive Regulation Of Hair Follicle Cell Proliferation Locomotion Immune Response Regulation Of Immune System Process Signaling Integrin-mediated Signaling Pathway Defense Response Cell Communication Regulation Of Body Fluid Levels Actin Filament Branching Submandibular Salivary Gland Formation Wound Healing Chemotaxis Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial Cell Migration Movement Of Cell Or Subcellular Component Netrin-activated Signaling Pathway Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Tagcloud ?		a4 ace2 affective affectivity bonferroni combine converting correction endoperoxide exceeded gated nociceptive nonspecific oppera orofacial phenotypes prostaglandin ptgs1 rs10809907 rs1514280 rs3842803 rs466448 rs6432860 scn1a summation temporomandibular thresholds tmd	avenues breakthrough checkpoint constituted counteract ctla4 employ helped immunomodulatory immunotherapies immunotherapy interface l1 lethal mcsp melanoma modalities perhaps promise recognised recognising redirect restrict spread standing subsets tumour unexplored vasculature
Tagcloud (Difference) ?		a4 ace2 affective affectivity bonferroni combine converting correction endoperoxide exceeded gated nociceptive nonspecific oppera orofacial phenotypes prostaglandin ptgs1 rs10809907 rs1514280 rs3842803 rs466448 rs6432860 scn1a summation temporomandibular thresholds tmd	avenues breakthrough checkpoint constituted counteract ctla4 employ helped immunomodulatory immunotherapies immunotherapy interface l1 lethal mcsp melanoma modalities perhaps promise recognised recognising redirect restrict spread standing subsets tumour unexplored vasculature
Tagcloud (Intersection) ?