EEF1D and ALX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EEF1D	ALX1
Description		eukaryotic translation elongation factor 1 delta	ALX homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Heat Shock Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cytoplasmic Translational Elongation Translation Translational Elongation Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Ionizing Radiation	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Development Embryonic Limb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Embryonic Skeletal System Morphogenesis Stem Cell Development Roof Of Mouth Development
Pathways		Eukaryotic Translation Elongation
Drugs
Diseases			Frontonasal dysplasia
GWAS		Schizophrenia ( 31268507)	Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nonsyndromic cleft lip ( 31609978) Nose size ( 27182965)
Interacting Genes		45 interacting genes: ALX1 APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CEBPA CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 FILNC1 FKBP6 FOS FRA10AC1 GARS1 HEXD KARS1 KTN1 LINC01232 MAP1B NR2F1 POT1 PRKCA RELA RNF20 RNF40 RPS6KA1 SIAH1 SIAH2 SLC26A4-AS1 SNCA TERF1 TINF2 TPT1 UBE2A USP40 USP7 VARS1	17 interacting genes: ALX4 APCS CLIC3 CREBBP EEF1D EP300 GRP IPO13 KAT5 KRTAP4-4 OR52L1 PACRGL RARA RBM45 SRA1 UROC1 ZNF300
Entrez ID		1936	8092
HPRD ID		00560	03316
Ensembl ID		ENSG00000104529	ENSG00000180318
Uniprot IDs		B2RAR6 P29692	Q15699 V9HWA7
PDB IDs		2MVM 2MVN 2N51 5JPO
Enriched GO Terms of Interacting Partners?		Protein Metabolic Process Shelterin Complex HULC Complex Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Amyloid Fibril Formation Negative Regulation Of Biosynthetic Process Nuclear Telomere Cap Complex Positive Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Telomere Capping TRNA Aminoacylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nucleic Acid Metabolic Process Diadenosine Tetraphosphate Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Chromatin Binding Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation Telomere Assembly Chromatin Organization Regulation Of Protein Catabolic Process Telomeric DNA Binding Nucleus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Interleukin-1 Regulation Of Synapse Assembly Cytosol Negative Regulation Of DNA Biosynthetic Process Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Copper Ion Response To Peptide Regulation Of Establishment Of Protein Localization To Telomere DNA Metabolic Process DNA-binding Transcription Factor Binding Response To Xenobiotic Stimulus Nucleoplasm Regulation Of Primary Metabolic Process Ankyrin Repeat Binding	Peptide Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Acetylation Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Transcription Regulator Complex Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone Acetyltransferase Activity Protein Acetylation Transcription Coactivator Binding DNA-binding Transcription Factor Binding N-terminal Protein Amino Acid Acetylation Histone H4 Acetyltransferase Activity Chromatin DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Myoblast Differentiation Acyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Radiation Regulation Of Defense Response Regulation Of Hemopoiesis Innate Immune Response-activating Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Radiation Tau Protein Binding Positive Regulation Of Defense Response Positive Regulation Of Leukocyte Differentiation Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity
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