EEF1D and FKBP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EEF1D	FKBP6
Description		eukaryotic translation elongation factor 1 delta	FKBP prolyl isomerase family member 6 (inactive)
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex	Synaptonemal Complex Fibrillar Center Nucleus Cytoplasm Cytosol Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Heat Shock Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Identical Protein Binding Hsp90 Protein Binding
	Biological Process	Cytoplasmic Translational Elongation Translation Translational Elongation Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Ionizing Radiation	Protein Folding Spermatogenesis Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Positive Regulation Of Viral Genome Replication Meiotic Cell Cycle Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		Eukaryotic Translation Elongation	Meiotic synapsis PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Schizophrenia ( 31268507)	Height ( 31562340) Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		45 interacting genes: ALX1 APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CEBPA CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 FILNC1 FKBP6 FOS FRA10AC1 GARS1 HEXD KARS1 KTN1 LINC01232 MAP1B NR2F1 POT1 PRKCA RELA RNF20 RNF40 RPS6KA1 SIAH1 SIAH2 SLC26A4-AS1 SNCA TERF1 TINF2 TPT1 UBE2A USP40 USP7 VARS1	38 interacting genes: ACD ALDH3A1 CCDC198 CCNK CDK5RAP3 CFP CFTR CRACR2A DDIT4L DLGAP4 ECM1 EEF1D ENKD1 FAM107A GAPDH GSC2 HSP90AA1 IHO1 KANK2 KRT75 LZTS2 MAP3K1 MEI4 MEOX2 NME7 NTAQ1 PIAS2 PICK1 RAB11FIP2 RNF4 SAXO4 SUMO1P1 TEPSIN TINF2 TMEM9B TRIM55 TRIM63 ZNF655
Entrez ID		1936	8468
HPRD ID		00560	05326
Ensembl ID		ENSG00000104529	ENSG00000077800
Uniprot IDs		B2RAR6 P29692	O75344
PDB IDs		2MVM 2MVN 2N51 5JPO	3B7X
Enriched GO Terms of Interacting Partners?		Protein Metabolic Process Shelterin Complex HULC Complex Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Amyloid Fibril Formation Negative Regulation Of Biosynthetic Process Nuclear Telomere Cap Complex Positive Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Telomere Capping TRNA Aminoacylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nucleic Acid Metabolic Process Diadenosine Tetraphosphate Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Chromatin Binding Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation Telomere Assembly Chromatin Organization Regulation Of Protein Catabolic Process Telomeric DNA Binding Nucleus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Interleukin-1 Regulation Of Synapse Assembly Cytosol Negative Regulation Of DNA Biosynthetic Process Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Copper Ion Response To Peptide Regulation Of Establishment Of Protein Localization To Telomere DNA Metabolic Process DNA-binding Transcription Factor Binding Response To Xenobiotic Stimulus Nucleoplasm Regulation Of Primary Metabolic Process Ankyrin Repeat Binding	Shelterin Complex Telomere Assembly Meiotic DNA Double-strand Break Formation Protein Binding Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Chromosome, Telomeric Region
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