EDN1 and CMA1

Number of citations of the paper that reports this interaction (PubMedID 9257865)
0

Data Source:
HPRD (in vitro)

		EDN1	CMA1
Description		endothelin 1	chymase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Transport Vesicle Weibel-Palade Body Basal Part Of Cell Rough Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Cytosol Secretory Granule Extracellular Matrix Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Endothelin A Receptor Binding Endothelin B Receptor Binding Receptor Ligand Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Peptide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Histamine Secretion Response To Amphetamine Heart Process Glomerular Filtration Regulation Of Systemic Arterial Blood Pressure By Endothelin Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Regulation Of PH Smooth Muscle Contraction Mitochondrion Organization Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Axon Guidance Heart Development Respiratory Gaseous Exchange By Respiratory System Body Fluid Secretion Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Dorsal/ventral Pattern Formation Response To Ozone Positive Regulation Of Heart Rate Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Regulation Of D-glucose Transmembrane Transport Neural Crest Cell Development Neural Crest Cell Differentiation Neural Crest Cell Fate Commitment Response To Activity Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Peptide Hormone Secretion Nitric Oxide Transport Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Thyroid Gland Development Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Testosterone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Prostaglandin F Embryonic Heart Tube Development Response To Nicotine Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Muscle Stretch Epithelial Fluid Transport Vasoconstriction Middle Ear Morphogenesis Positive Regulation Of Odontogenesis Superoxide Anion Generation Positive Regulation Of Canonical NF-kappaB Signal Transduction Rhythmic Excitation Response To Amino Acid Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Cellular Response To Human Chorionic Gonadotropin Stimulus Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of JNK Cascade Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Axon Extension Positive Regulation Of Calcium-mediated Signaling Cartilage Development Negative Regulation Of Protein Metabolic Process Membrane Depolarization Canonical Wnt Signaling Pathway Maternal Process Involved In Parturition Positive Regulation Of Sarcomere Organization Axonogenesis Involved In Innervation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Chemokine-mediated Signaling Pathway Renal Sodium Ion Absorption Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Glomerular Endothelium Development Podocyte Differentiation Endothelin Receptor Signaling Pathway Endothelin Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Neutrophil Chemotaxis Cellular Response To Toxic Substance Sympathetic Neuron Axon Guidance Blood Vessel Diameter Maintenance CAMP/PKA Signal Transduction Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Salt Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Cation Channel Activity	Angiotensin Maturation Proteolysis Peptide Metabolic Process Protein Processing Extracellular Matrix Disassembly Protein Catabolic Process Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Regulation Of Inflammatory Response Protein Maturation Cellular Response To Glucose Stimulus Cytokine Precursor Processing
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins
Drugs		TBC-3711	Benzylsulfonic acid 2-(N-morpholino)ethanesulfonic acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases
GWAS		Body mass index ( 26426971) Circulating vasoactive peptide levels ( 23381795) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hematocrit ( 32888494) Hemoglobin ( 32888494) Multiple system atrophy ( 27629089) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494)
Interacting Genes		10 interacting genes: ADM BAG6 CMA1 COPS6 ECE1 EDNRA EDNRB KEL MME UBQLN4	10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3
Entrez ID		1906	1215
HPRD ID		07030	00346
Ensembl ID		ENSG00000078401	ENSG00000092009
Uniprot IDs		P05305 Q6FH53	P23946 Q4FEB3
PDB IDs		1EDN 1EDP 1T7H 1V6R 5GLH 6DK5 8HCQ 8HCX 8IY5 8IY6 8XGR 8XVE 8XVH 8XVI 8XWP 8XWQ 8ZRT	1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP 7H60 7H61 7H62 7H63 7H64 7H65 7H66 7H67 7H68 7H69 7H6A 7H6B 7H6C 7H6D 7H6E 7H6F 7H6I 9GBH 9GC1 9GC9 9GCC 9GCD
Enriched GO Terms of Interacting Partners?		Blood Vessel Diameter Maintenance Regulation Of Tube Size Vascular Process In Circulatory System Endothelin Receptor Activity Circulatory System Process Protein Metabolic Process Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Substance P Catabolic Process Vasoconstriction Peptide Hormone Processing Regulation Of Blood Pressure Signaling Receptor Ligand Precursor Processing Sympathetic Neuron Axon Guidance Renal Albumin Absorption Protein Processing Peptidase Activity Hormone Metabolic Process Neuropeptide Catabolic Process Peptide Metabolic Process Regulation Of Hormone Levels Bradykinin Catabolic Process Renal Protein Absorption Regulation Of Blood Circulation Regulation Of Biological Quality Axonogenesis Involved In Innervation Vascular Associated Smooth Muscle Cell Development Endopeptidase Activity Angiotensin Maturation Proteolysis Metalloendopeptidase Activity Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Muscle Cell Development Protein Maturation Regulation Of Heart Rate Hormone Catabolic Process Developmental Pigmentation Vascular Associated Smooth Muscle Contraction Renal System Process Peptide Catabolic Process Metallopeptidase Activity Regulation Of Urine Volume System Process Renal Sodium Ion Absorption Embryonic Heart Tube Development Renal Sodium Ion Transport Macromolecule Metabolic Process Peptide Binding	Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Vein Smooth Muscle Contraction Leukocyte Migration Vasoconstriction Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Myeloid Leukocyte Migration Regulation Of Systemic Arterial Blood Pressure Regulation Of Locomotion Positive Regulation Of Prostaglandin Biosynthetic Process Artery Smooth Muscle Contraction Neutrophil Chemotaxis Tonic Smooth Muscle Contraction Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Regulation Of Prostaglandin Biosynthetic Process Regulation Of Vasoconstriction Neutrophil Migration Granulocyte Chemotaxis Vascular Associated Smooth Muscle Contraction Granulocyte Migration Positive Regulation Of Fatty Acid Biosynthetic Process Hormone Activity Positive Regulation Of Heart Rate Positive Regulation Of Cellular Component Organization Circulatory System Process Regulation Of Lipid Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Lipid Metabolic Process Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Heart Contraction Positive Regulation Of Fatty Acid Metabolic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Small Molecule Metabolic Process Extracellular Region Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Muscle Contraction System Process Extracellular Space Cell Migration
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