EDN1 and MME

Number of citations of the paper that reports this interaction (PubMedID 2201681)
0

Data Source:
HPRD (in vitro)

		EDN1	MME
Description		endothelin 1	membrane metalloendopeptidase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Transport Vesicle Weibel-Palade Body Basal Part Of Cell Rough Endoplasmic Reticulum Lumen	Extracellular Region Nucleoplasm Cytoplasm Early Endosome Trans-Golgi Network Centrosome Cytosol Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Cell Surface Membrane Axon Dendrite Secretory Granule Membrane Cytoplasmic Vesicle Ciliary Basal Body Neuronal Cell Body Neuron Projection Terminus Membrane Raft Synapse Extracellular Exosome Presynapse
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Endothelin A Receptor Binding Endothelin B Receptor Binding Receptor Ligand Activity	Phosphatidylserine Binding Endopeptidase Activity Metallocarboxypeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Exopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Binding Protein Homodimerization Activity Metal Ion Binding Oligopeptidase Activity Cardiolipin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Skeletal System Development Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Histamine Secretion Response To Amphetamine Heart Process Glomerular Filtration Regulation Of Systemic Arterial Blood Pressure By Endothelin Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Regulation Of PH Smooth Muscle Contraction Mitochondrion Organization Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Axon Guidance Heart Development Respiratory Gaseous Exchange By Respiratory System Body Fluid Secretion Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Dorsal/ventral Pattern Formation Response To Ozone Positive Regulation Of Heart Rate Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Regulation Of D-glucose Transmembrane Transport Neural Crest Cell Development Neural Crest Cell Differentiation Neural Crest Cell Fate Commitment Response To Activity Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Calcium-mediated Signaling Signal Transduction Involved In Regulation Of Gene Expression Peptide Hormone Secretion Nitric Oxide Transport Negative Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Thyroid Gland Development Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Testosterone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Response To Prostaglandin F Embryonic Heart Tube Development Response To Nicotine Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Muscle Stretch Epithelial Fluid Transport Vasoconstriction Middle Ear Morphogenesis Positive Regulation Of Odontogenesis Superoxide Anion Generation Positive Regulation Of Canonical NF-kappaB Signal Transduction Rhythmic Excitation Response To Amino Acid Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Leptin Cellular Response To Human Chorionic Gonadotropin Stimulus Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of JNK Cascade Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Axon Extension Positive Regulation Of Calcium-mediated Signaling Cartilage Development Negative Regulation Of Protein Metabolic Process Membrane Depolarization Canonical Wnt Signaling Pathway Maternal Process Involved In Parturition Positive Regulation Of Sarcomere Organization Axonogenesis Involved In Innervation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Chemokine-mediated Signaling Pathway Renal Sodium Ion Absorption Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Response To Dexamethasone Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Glomerular Endothelium Development Podocyte Differentiation Endothelin Receptor Signaling Pathway Endothelin Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Neutrophil Chemotaxis Cellular Response To Toxic Substance Sympathetic Neuron Axon Guidance Blood Vessel Diameter Maintenance CAMP/PKA Signal Transduction Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Salt Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Cation Channel Activity	Kidney Development Placenta Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Learning Or Memory Substance P Catabolic Process Bradykinin Catabolic Process Protein Processing Sensory Perception Of Pain Protein Catabolic Process Lung Development Hormone Catabolic Process Response To Estrogen Creatinine Metabolic Process Amyloid-beta Metabolic Process Positive Regulation Of Neurogenesis Neuropeptide Processing Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence Amyloid-beta Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Long-term Synaptic Potentiation
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Metabolism of Angiotensinogen to Angiotensins Physiological factors Neutrophil degranulation Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		TBC-3711	Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
Diseases
GWAS		Body mass index ( 26426971) Circulating vasoactive peptide levels ( 23381795) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hematocrit ( 32888494) Hemoglobin ( 32888494) Multiple system atrophy ( 27629089) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494)	Diastolic blood pressure ( 27841878) Primary sclerosing cholangitis ( 27992413) Systolic blood pressure ( 27841878) Triglyceride levels in HIV infection ( 33109212) Vaginal microbiome composition (Shannon diversity index) ( 32723796)
Interacting Genes		10 interacting genes: ADM BAG6 CMA1 COPS6 ECE1 EDNRA EDNRB KEL MME UBQLN4	20 interacting genes: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 EZR GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 PTEN SHC1 SNCA TMEM132D VIP
Entrez ID		1906	4311
HPRD ID		07030	00392
Ensembl ID		ENSG00000078401	ENSG00000196549
Uniprot IDs		P05305 Q6FH53	P08473 Q3KQS6
PDB IDs		1EDN 1EDP 1T7H 1V6R 5GLH 6DK5 8HCQ 8HCX 8IY5 8IY6 8XGR 8XVE 8XVH 8XVI 8XWP 8XWQ 8ZRT	1DMT 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH 5JMY 6GID 6SH1 6SH2 6SUK 6SVY 6THP 6XVP
Enriched GO Terms of Interacting Partners?		Blood Vessel Diameter Maintenance Regulation Of Tube Size Vascular Process In Circulatory System Endothelin Receptor Activity Circulatory System Process Protein Metabolic Process Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Substance P Catabolic Process Vasoconstriction Peptide Hormone Processing Regulation Of Blood Pressure Signaling Receptor Ligand Precursor Processing Sympathetic Neuron Axon Guidance Renal Albumin Absorption Protein Processing Peptidase Activity Hormone Metabolic Process Neuropeptide Catabolic Process Peptide Metabolic Process Regulation Of Hormone Levels Bradykinin Catabolic Process Renal Protein Absorption Regulation Of Blood Circulation Regulation Of Biological Quality Axonogenesis Involved In Innervation Vascular Associated Smooth Muscle Cell Development Endopeptidase Activity Angiotensin Maturation Proteolysis Metalloendopeptidase Activity Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Muscle Cell Development Protein Maturation Regulation Of Heart Rate Hormone Catabolic Process Developmental Pigmentation Vascular Associated Smooth Muscle Contraction Renal System Process Peptide Catabolic Process Metallopeptidase Activity Regulation Of Urine Volume System Process Renal Sodium Ion Absorption Embryonic Heart Tube Development Renal Sodium Ion Transport Macromolecule Metabolic Process Peptide Binding	Hormone Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Blood Vessel Diameter Maintenance Regulation Of Tube Size Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Biological Quality Positive Regulation Of Heart Contraction Intracellular Signal Transduction Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Protein Metabolic Process Signaling Receptor Binding Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade Vascular Process In Circulatory System Extracellular Region Positive Regulation Of Small Molecule Metabolic Process Regulation Of Vasoconstriction Signal Release Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Regulation Of Blood Pressure Circulatory System Process Negative Regulation Of MAPK Cascade Regulation Of Locomotion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Cell-cell Signaling Regulation Of Transport Regulation Of Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hormone Secretion Protein Kinase CK2 Complex
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