EBF1 and PAX5

Number of citations of the paper that reports this interaction (PMID 14594818)
6

Data Source:
HPRD (in vitro)

		EBF1	PAX5
Gene Name		early B-cell factor 1	paired box 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding Protein Dimerization Activity C2H2 Zinc Finger Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding
	Biological Process	Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Humoral Immune Response Multicellular Organismal Development Spermatogenesis Nervous System Development Organ Morphogenesis Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Histone H3-K9 Methylation
Pathways		Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Blood pressure ( 21909110) Breast cancer ( 23535729 23535733) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Obesity-related traits ( 23251661) Systolic blood pressure ( 21909115)	Intelligence ( 22449649) Obesity and blood pressure ( 22013104)
Protein-Protein Interactions		6 interactors: ATPAF2 CREBBP HOMEZ PAX5 ZNF423 ZNF521	14 interactors: CREBBP DAXX EBF1 EP300 ETS1 ID2 ID3 KPNA1 KPNA2 MYB RB1 RUNX1 TBP TLE4
Entrez ID		1879	5079
HPRD ID		01256	01334
Ensembl ID		ENSG00000164330	ENSG00000196092
Uniprot IDs		Q9UH73	C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548
PDB IDs		3LYR 3MQI	1K78 1MDM
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Notch Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Proton-transporting ATP Synthase Complex Assembly N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Germ-line Stem Cell Maintenance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Histone Methylation Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of BMP Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Histone Methylation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Skeletal Muscle Cell Differentiation Cellular Response To Heat Multicellular Organismal Development Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Viral Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Metabolic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cell Differentiation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Chromatin Modification Positive Regulation Of Macrophage Differentiation N-terminal Protein Amino Acid Acetylation Rhythmic Process Embryo Development Mitotic Cell Cycle Process
Tagcloud ?		collaborate concert coordinate cues decades e2a epigenetic establish establishing extrinsic fate fates foxo1 guide ikaros landscape lineage lineages lock loops lymphopoiesis modifiers modify pax permissive prime pu repress runx1	aldo aldob aldolase ambp anchor anonymous backcross bikunin d4h9s3e d4nds4 d9s3 dehydratase galt hexabrachion homologues hsa9 hsa9q hxb ifa interspecific levulinate localizations mmu4 orm orosomucoid synteny typed tyrp
Tagcloud (Difference) ?		collaborate concert coordinate cues decades e2a epigenetic establish establishing extrinsic fate fates foxo1 guide ikaros landscape lineage lineages lock loops lymphopoiesis modifiers modify permissive prime pu repress runx1	aldo aldob aldolase ambp anchor anonymous backcross bikunin d4h9s3e d4nds4 d9s3 dehydratase galt hexabrachion homologues hsa9 hsa9q hxb ifa interspecific levulinate localizations mmu4 orm orosomucoid synteny typed tyrp
Tagcloud (Intersection) ?		pax