E2F4 and NDN

Number of citations of the paper that reports this interaction (PMID 12198120)
16

Data Source:
HPRD (in vitro, in vivo)

		E2F4	NDN
Gene Name		E2F transcription factor 4, p107/p130-binding	necdin, melanoma antigen (MAGE) family member
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Nucleus Centrosome Cytosol Cell Projection Perikaryon
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding	DNA Binding Gamma-tubulin Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Epithelial Cell Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Volume Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Cell Size Organ Morphogenesis Gene Expression Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Centriole Assembly Multi-ciliated Epithelial Cell Differentiation	Neuron Migration Respiratory System Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nervous System Development Axonal Fasciculation Central Nervous System Development Negative Regulation Of Cell Proliferation Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Axon Extension Multicellular Organismal Homeostasis Genetic Imprinting
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A FHL2 HCFC1 ID3 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1	43 interactors: APBB1IP ARSE BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 LAX1 LPXN MIER2 MKRN2 MPP6 N6AMT2 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PJA1 PPFIA1 SERTAD3 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B
Entrez ID		1874	4692
HPRD ID		02806	03667
Ensembl ID		ENSG00000205250	ENSG00000182636
Uniprot IDs		Q16254	Q99608
PDB IDs		1CF7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Cycle Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Cycle Process Regulation Of Centrosome Duplication Androgen Receptor Signaling Pathway Regulation Of Centrosome Cycle Negative Regulation Of Centriole Replication	Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Anterograde Axon Cargo Transport Regulation Of Fibroblast Proliferation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels RNA Metabolic Process Cellular Response To Oxygen Levels Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Gene Expression Response To Wounding Regulation Of Gene Expression Transcription, DNA-templated Microtubule-based Movement RNA Biosynthetic Process Cellular Localization Positive Regulation Of Fibroblast Proliferation Circadian Rhythm MRNA Transcription From RNA Polymerase II Promoter Cell Differentiation Wound Healing Regulation Of Thymocyte Apoptotic Process MRNA Transcription Transcription From RNA Polymerase II Promoter Developmental Process Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Anterograde Synaptic Vesicle Transport Regulation Of Establishment Of Protein Localization Establishment Of Localization In Cell Positive Regulation Of Natural Killer Cell Activation Melanosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Pigment Granule Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Embryonic Placenta Development Regulation Of Cellular Localization Tissue Remodeling Iron Ion Homeostasis MRNA Stabilization Cell Morphogenesis Microtubule-based Process Anatomical Structure Development
Tagcloud ?		adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary	biallelically cancerous cdkn1c coordinately deregulated deregulating deregulation dmr dmrs exclusive h19 hoxc6 hyper hypo igf2 ign imprinted imprinting lit1 meg3 plagl1 ppp1r9a presumptive prostatic pyrosequencing qrt silico wondered zac1
Tagcloud (Difference) ?		adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary	biallelically cancerous cdkn1c coordinately deregulated deregulating deregulation dmr dmrs exclusive h19 hoxc6 hyper hypo igf2 ign imprinted imprinting lit1 meg3 plagl1 ppp1r9a presumptive prostatic pyrosequencing qrt silico wondered zac1
Tagcloud (Intersection) ?