E2F4 and SPIB

Number of citations of the paper that reports this interaction (PubMedID 12748276)
56

Data Source:
BioGRID (two hybrid)

		E2F4	SPIB
Description		E2F transcription factor 4	Spi-B transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis Blood Circulation Regulation Of Cell Size Animal Organ Morphogenesis Cell Projection Organization Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Centriole Assembly Multi-ciliated Epithelial Cell Differentiation	Immature B Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Primary biliary cholangitis ( 20639880 21399635 26394269) Systolic blood pressure ( 30224653)
Interacting Genes		34 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RECQL RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRIM33 TRRAP USP2 XPO1	19 interacting genes: CEBPB CREBBP CSNK2A1 CSNK2A2 E2F1 E2F2 E2F3 E2F4 EP300 GATA1 IRF4 JUN MAPK3 MAPK8 RB1 SPI1 SSB TBP TMEM37
Entrez ID		1874	6689
HPRD ID		02806	06007
Ensembl ID		ENSG00000205250	ENSG00000269404
Uniprot IDs		Q16254	Q01892
PDB IDs		1CF7 5TUU
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Regulation Of Lipid Kinase Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromatin Positive Regulation Of Metabolic Process Co-SMAD Binding Chromatin Organization DNA Binding Regulation Of Cell Cycle Process IkappaB Kinase Activity Paraxial Mesoderm Morphogenesis Promoter-specific Chromatin Binding R-SMAD Binding Cell Differentiation BHLH Transcription Factor Binding Ubiquitin Protein Ligase Binding Mesoderm Morphogenesis Rb-E2F Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle	Transcription Regulator Complex Chromatin Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Nucleoplasm RNA Polymerase II Transcription Regulator Complex Transcription Cis-regulatory Region Binding Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Apoptotic Process DNA-binding Transcription Activator Activity Rb-E2F Complex DNA-binding Transcription Factor Activity Cell Death Programmed Cell Death RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Myeloid Cell Differentiation DNA-templated Transcription Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process DNA Binding Sequence-specific DNA Binding Chromatin Binding Negative Regulation Of Metabolic Process Histone H3K27 Acetyltransferase Activity Regulation Of Apoptotic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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