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RARA and NPAS2
Number of citations of the paper that reports this interaction (PubMedID
11439184
)
0
Data Source:
BioGRID
(pull down)
HPRD
(two hybrid, in vitro)
RARA
NPAS2
Description
retinoic acid receptor alpha
neuronal PAS domain protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
CLOCK-BMAL Transcription Complex
Molecular Function
MRNA Regulatory Element Binding Translation Repressor Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity
Transcription Coactivator Binding
Retinoic Acid Binding
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Histone Deacetylase Binding
Protein Kinase B Binding
Sequence-specific DNA Binding
Retinoic Acid-responsive Element Binding
Metal Ion Binding
MRNA 5'-UTR Binding
Protein Kinase A Binding
Alpha-actinin Binding
Heterocyclic Compound Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Metal Ion Binding
Protein Dimerization Activity
Hsp90 Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Neural Tube Closure
Liver Development
Glandular Epithelial Cell Development
Outflow Tract Septum Morphogenesis
Growth Plate Cartilage Development
Regulation Of DNA-templated Transcription
Protein Phosphorylation
Germ Cell Development
Spermatogenesis
Female Pregnancy
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Translation
Hippocampus Development
Cell Differentiation
Prostate Gland Development
Regulation Of Granulocyte Differentiation
Negative Regulation Of Granulocyte Differentiation
Embryonic Camera-type Eye Development
Regulation Of Myelination
Response To Estradiol
Response To Retinoic Acid
Negative Regulation Of Type II Interferon Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Response To Vitamin A
Response To Cytokine
Multicellular Organism Growth
MRNA Transcription By RNA Polymerase II
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Response To Ethanol
Negative Regulation Of Cell Differentiation
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Binding
Ventricular Cardiac Muscle Cell Differentiation
Sertoli Cell Fate Commitment
Limb Development
Face Development
Bone Development
Trachea Cartilage Development
Chondroblast Differentiation
Negative Regulation Of Cartilage Development
Cellular Response To Lipopolysaccharide
Cellular Response To Retinoic Acid
Cellular Response To Estrogen Stimulus
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Regulation Of Hematopoietic Progenitor Cell Differentiation
Negative Regulation Of MiRNA Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Central Nervous System Development
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Circadian Regulation Of Gene Expression
Positive Regulation Of DNA Repair
Positive Regulation Of DNA-templated Transcription
Rhythmic Process
Response To Redox State
Positive Regulation Of Behavioral Fear Response
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
TGFBR3 expression
BMAL1:CLOCK,NPAS2 activates circadian expression
PPARA activates gene expression
Heme signaling
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Adapalene
Acitretin
Alitretinoin
Tretinoin
Tazarotene
Etretinate
Isotretinoin
Tamibarotene
LGD-1550
Trifarotene
Diseases
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
Acute myeloid leukemia (AML)
GWAS
Asthma (
31619474
)
Aspartate aminotransferase levels (
33547301
)
Chronotype (
30696823
)
Creutzfeldt-Jakob disease (variant) (
22137330
)
Educational attainment (
25201988
)
Hip circumference adjusted for BMI (
34021172
)
Intraocular pressure (
30054594
31798171
31959993
)
Intraocular pressure and central corneal thickness (multi-trait analysis) (
31798171
)
Metabolite levels (
23823483
)
Obsessive-compulsive traits (
33531474
)
Platelet distribution width (
32888494
)
Pulse pressure (
27841878
)
White blood cell count (
32888494
)
Interacting Genes
96 interacting genes:
ACTN4
AKT1
ALOX15B
ALX1
ARID1A
ARID5A
BAG1
BBS4
BMAL1
BTG1
CCND3
CCNDBP1
CDK7
CEBPA
CLOCK
CNOT1
COPS2
E2F1
ESR1
FGFR1
FN1
FOXO1
GADD45G
GATA2
HDAC1
HDAC3
HDAC4
HMGA1
HR
IRX4
ITGB1BP2
KAT2B
KDM5A
KLF5
LRIF1
MAPK6
MCRS1
MDM2
MECR
MED1
MED25
MED6
MMS19
NCOA1
NCOA2
NCOA3
NCOA6
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR2C1
NR2E3
NR3C1
NRBF2
NRIP1
NRIP2
NSD1
PARP1
PHF8
PIN1
PLEKHF2
PML
PNRC2
POU2F1
PRAME
PRDX6
PRKCA
PSMC5
RXRA
RXRB
RXRG
S100A3
SIRT1
SMARCD3
SNW1
SP1
SPEN
SRC
SRF
STAT5B
TADA3
TEKT4
THRB
TNIP1
TOP2B
TRIM24
TRIP4
UBE3A
UBQLN1
UBR5
USP7
ZBTB16
29 interacting genes:
ARNT
ARNT2
BMAL1
BPIFA1
CREBBP
CRX
CRY1
CRY2
CSNK2B
DELEC1
EFS
EP300
HESX1
HGS
HSP90AA1
INCA1
KAT2B
NCK2
NCOA3
NGLY1
RARA
RASSF7
RHOXF1
RORC
RPL6
RXRA
TRAF4
UBAP2
ZSCAN1
Entrez ID
5914
4862
HPRD ID
06769
09137
Ensembl ID
ENSG00000131759
ENSG00000170485
Uniprot IDs
A8K840
A8MUP8
F1D8N9
P10276
Q6I9R7
A2I2P5
Q99743
PDB IDs
1DKF
1DSZ
3A9E
3KMR
3KMZ
4DQM
5K13
6XWG
7AOS
7APO
7QAA
7WQQ
9GFE
9GFI
Enriched GO Terms of Interacting Partners
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Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Nucleus
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Positive Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Chromatin
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
Nuclear Retinoic Acid Receptor Binding
Nuclear Receptor Binding
Nuclear Receptor-mediated Signaling Pathway
Negative Regulation Of Metabolic Process
Hormone-mediated Signaling Pathway
Intracellular Receptor Signaling Pathway
Response To Hormone
Nuclear Retinoid X Receptor Binding
Rhythmic Process
Transcription Regulator Complex
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Transcription Coactivator Activity
Retinoic Acid Receptor Signaling Pathway
Sequence-specific DNA Binding
Regulation Of Developmental Process
Chromatin Binding
Nuclear Estrogen Receptor Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin DNA Binding
Chromatin
Transcription Regulator Complex
Intracellular Receptor Signaling Pathway
N-terminal Peptidyl-lysine Acetylation
Nuclear Receptor Binding
Regulation Of Primary Metabolic Process
Sequence-specific Double-stranded DNA Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Protein-lysine-acetyltransferase Activity
Regulation Of Metabolic Process
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Regulation Of DNA-templated Transcription
Aryl Hydrocarbon Receptor Binding
Regulation Of RNA Biosynthetic Process
Aryl Hydrocarbon Receptor Complex
Rhythmic Process
Histone Acetyltransferase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
N-terminal Protein Amino Acid Acetylation
Positive Regulation Of Biosynthetic Process
Peptidyl-lysine Acetylation
Positive Regulation Of Macromolecule Metabolic Process
Nuclear Receptor Activity
DNA Binding
Transcription Coregulator Activity
Negative Regulation Of Transcription By RNA Polymerase II
Histone H3K27 Acetyltransferase Activity
Blue Light Signaling Pathway
DNA (6-4) Photolyase Activity
Deoxyribodipyrimidine Photo-lyase Activity
Blue Light Photoreceptor Activity
Circadian Rhythm
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Acetyltransferase Activity
Hormone-mediated Signaling Pathway
Circadian Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Modification Process
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