RARA and FOXO1

Number of citations of the paper that reports this interaction (PMID 11353774)
49

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		RARA	FOXO1
Gene Name		retinoic acid receptor, alpha	forkhead box O1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cell Surface Actin Cytoskeleton Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Translation Repressor Activity, Nucleic Acid Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Retinoic Acid Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Transcription Coactivator Activity Transcription Corepressor Activity Receptor Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Chromatin DNA Binding Phosphatidylinositol 3-kinase Regulator Activity Protein Kinase B Binding Retinoic Acid-responsive Element Binding Protein Heterodimerization Activity MRNA 5'-UTR Binding Protein Kinase A Binding Alpha-actinin Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Neural Tube Closure Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Signal Transduction Germ Cell Development Spermatogenesis Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Intracellular Estrogen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Granulocyte Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Response To Estradiol Response To Retinoic Acid Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Response To Vitamin A Response To Cytokine Multicellular Organism Growth Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Steroid Hormone Mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Binding Positive Regulation Of Protein Kinase B Signaling Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Sertoli Cell Fate Commitment Limb Development Face Development Trachea Cartilage Development Chondroblast Differentiation Negative Regulation Of Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Estrogen Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Temperature Homeostasis Cellular Glucose Homeostasis Transcription From RNA Polymerase II Promoter Protein Acetylation Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Starvation Positive Regulation Of Autophagy Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Cold Cellular Response To Hyperoxia Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Energy Homeostasis
Pathways		Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Regulation of beta-cell development PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Regulation of gene expression in beta cells Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Adapalene Acitretin Alitretinoin Tazarotene Etretinate Isotretinoin Tamibarotene
Diseases
GWAS			Central corneal thickness ( 20485516 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		86 interactors: AKT1 ARID1A ARID5A ARNTL BAG1 BTG1 CCND3 CDK7 CEBPA CLOCK CNOT1 COPS2 E2F1 ESR1 FN1 FOXO1 GADD45G GATA2 HDAC1 HDAC3 HDAC4 HMGA1 HR IRX4 ITGB1BP2 KAT2B KDM5A KLF5 LRIF1 MAPK6 MECR MED1 MED25 MED6 MMS19 NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR2E3 NR3C1 NR4A2 NRBF2 NRIP1 NRIP2 NSD1 PARP1 PHF8 PIN1 PML PNRC2 POU2F1 PRAME PRDX6 PRKCA PSMC5 RAC3 RXRA RXRB RXRG SIRT1 SMARCD3 SMARCE1 SNW1 SP1 SPEN SRC STAT5B TADA3 TEKT4 THRB TNIP1 TOP2B TRIM24 TRIP4 UBE3A UBQLN1 USP7 ZBTB16	31 interactors: AKT1 AR CEBPB CREBBP CSNK1G1 CTNNB1 DYRK1A EP300 ESR1 FHL2 FOXG1 G6PC GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 PAK1 PARP1 PPARG RARA SIRT1 SMAD3 SMAD4 SRC THRB TXNRD1 YWHAG YWHAZ
Entrez ID		5914	2308
HPRD ID		06769	00645
Ensembl ID			ENSG00000150907
Uniprot IDs		A8K840 A8MUP8 B4E1J4 F1D8N9 P10276 Q6I9R7	Q12778
PDB IDs		1DKF 1DSZ 3A9E 3KMR 3KMZ 4DQM	3CO6 3CO7 3COA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Multicellular Organismal Development Rhythmic Process Developmental Process Cellular Response To Hormone Stimulus System Development Cellular Response To Organic Substance Organ Development Chromatin Modification	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Hormone Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Death Multicellular Organismal Development Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Anatomical Structure Development Regulation Of RNA Metabolic Process Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Apoptotic Process RNA Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process System Development Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Developmental Process Organ Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Gene Expression Regulation Of Signaling Tissue Development Regulation Of Protein Localization Regulation Of Metabolic Process Reproductive Structure Development Epithelium Development Reproductive System Development Transcription From RNA Polymerase II Promoter Regulation Of Establishment Of Protein Localization Epithelial Cell Differentiation Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		apl bodies compartmentalisation covalently dependant disrupted fits indirectly kr leukaemia localisation localises lys487 lys490 modification modifies mutagenesis named nd10 phosphoprotein pic1 pml pods promyelocytic rangap1 subcellular sumo translocated ubc9	adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction subcellular transfections woundhealing wst
Tagcloud (Difference) ?		apl bodies compartmentalisation covalently dependant disrupted fits indirectly kr leukaemia localisation localises lys487 lys490 modification modifies mutagenesis named nd10 phosphoprotein pic1 pml pods promyelocytic rangap1 sumo translocated ubc9	adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction transfections woundhealing wst
Tagcloud (Intersection) ?		subcellular