DAAM1 and DVL2

Number of citations of the paper that reports this interaction (PMID 11779461)
144

Data Source:
HPRD (in vivo)

		DAAM1	DVL2
Gene Name		dishevelled associated activator of morphogenesis 1	dishevelled segment polarity protein 2
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Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	Actin Binding Protein Binding Rho GTPase Binding Identical Protein Binding	Frizzled Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association
	Biological Process	Actin Cytoskeleton Organization	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Segment Specification Heart Development Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL Signaling by Hippo TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by WNT in cancer PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: AMBP B3GALT4 DVL1 DVL2 PRPF40A RHOA	61 interactors: AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DDI1 DPPA2 DYNLT1 ENKD1 FZD4 GABARAP GABARAPL1 ITCH LRRK2 MAP1LC3A MCRS1 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PRKCA PRKCB PRKCG PRPF3 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 SMURF1 SNF8 SNIP1 SORBS3 TCEB3B THAP1 TIFA TP53 TRAF2 U2AF2 USP5 VANGL1 VHL ZBTB8A ZNF165 ZNF250 ZNF263
Entrez ID		23002	1856
HPRD ID		09433	03690
Ensembl ID		ENSG00000100592	ENSG00000004975
Uniprot IDs		Q9Y4D1	I3L2N2 O14641
PDB IDs		2J1D 2Z6E	2REY 3CBX 3CBY 3CBZ 3CC0
Enriched GO Terms of Interacting Partners?		Convergent Extension Involved In Neural Plate Elongation Morphogenesis Of An Epithelial Sheet Convergent Extension Involved In Organogenesis Neural Plate Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Convergent Extension Neural Plate Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Non-canonical Wnt Signaling Pathway Cochlea Development Regulation Of Cytokinesis Morphogenesis Of An Epithelium Canonical Wnt Signaling Pathway Inner Ear Morphogenesis Regulation Of Embryonic Development Tissue Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Ear Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Skeletal Muscle Satellite Cell Migration Morphogenesis Of Embryonic Epithelium Regulation Of Organ Morphogenesis Regulation Of Stress-activated MAPK Cascade Inner Ear Development Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Collateral Sprouting Positive Regulation Of Neuron Projection Development Regulation Of Canonical Wnt Signaling Pathway Apolipoprotein A-I-mediated Signaling Pathway Ear Development Cleavage Furrow Formation Regulation Of Cell Division Epithelium Development Negative Regulation Of Signal Transduction Protein Localization To Microtubule Heme Catabolic Process Wnt Signaling Pathway Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Locomotion	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Activation Cellular Metabolic Process Regulation Of Cellular Process Cell Death Death Cellular Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Catabolic Process Negative Regulation Of Signaling Programmed Cell Death Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Membrane Organization Positive Regulation Of Protein Metabolic Process Viral Process Histone H3-T6 Phosphorylation Response To Transforming Growth Factor Beta
Tagcloud ?		0x 7x 8x axin1 camk2a canonical chp ctnnb1 dendrogram dkk3 dvl mapk8 nfat5 pituitaries pituitary plcb1 prickle prkca ptk7 reinforce secreting sequester sfrp1 spry1 tcf7 vangl1 wisp2 wnt11 wnt4	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Difference) ?		0x 7x 8x axin1 camk2a canonical chp ctnnb1 dendrogram dkk3 dvl mapk8 nfat5 pituitaries pituitary plcb1 prickle prkca ptk7 reinforce secreting sequester sfrp1 spry1 tcf7 vangl1 wisp2 wnt11 wnt4	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Intersection) ?