DAAM1 and AMBP

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		DAAM1	AMBP
Name		dishevelled associated activator of morphogenesis 1	alpha-1-microglobulin/bikunin precursor
Structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Motile Cilium Ciliary Basal Body Cell Projection Synapse Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Extracellular Matrix Nuclear Membrane Extracellular Exosome Blood Microparticle Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Calcium Channel Inhibitor Activity IgA Binding Heme Binding Carbohydrate Binding Peptidase Inhibitor Activity Chondroitin Sulfate Binding Protein Homodimerization Activity Calcium Oxalate Binding Collagen Fibril Binding
	Biological Process	Wnt Signaling Pathway Actin Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Presynaptic Actin Cytoskeleton Organization	Cell Adhesion Female Pregnancy Hemoglobin Metabolic Process Protein Catabolic Process Cellular Response To Reactive Oxygen Species Heme Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Immune Response Cellular Oxidant Detoxification Cytochrome C Metabolic Process
Pathways		PCP/CE pathway RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle	Scavenging of heme from plasma
GWAS		Brain morphology (MOSTest) ( 32665545 ) Cortical surface area ( 32963231 ) Cortical surface area (visual PC2) ( 32198502 ) Cortical thickness ( 32963231 ) Cortical volume ( 32963231 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Inferior temporal gyrus volume ( 31530798 ) Left–right brain asymmetry ( 33723403 ) Occipital lobe volume ( 31396565 ) Optic disc size ( 31809533 ) Parietal lobe volume ( 31396565 ) Parkinsonism in frontotemporal lobe dementia ( 29724592 ) Type 2 diabetes ( 25483131 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: KIAA0586	1 novel interactors: EXOSC2
Interacting Genes		7 interacting genes: AMBP B3GALT4 DVL1 DVL2 PRPF40A RHOA USP10	12 interacting genes: A2M ALB COX8A DAAM1 ENO1 F2 FHL3 FN1 GRB2 PIK3CA PIK3R3 STAT3
Entrez ID		23002	259
HPRD ID		09433	01467
Ensembl ID		ENSG00000100592	ENSG00000106927
Uniprot IDs		Q9Y4D1	P02760
PDB IDs		2J1D 2Z6E	1BIK 3QKG 4ES7 4U30 6EJ7 6EJ8 6EJ9 6EJA 6EJB 6EJC 6EJD
GO Terms Enriched among Interactors		Wnt Signaling Pathway, Planar Cell Polarity Pathway Convergent Extension Involved In Neural Plate Elongation Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Organogenesis Convergent Extension Involved In Gastrulation Positive Regulation Of Neuron Projection Arborization Epithelial Tube Morphogenesis Convergent Extension Regulation Of Neuron Projection Arborization Cochlea Morphogenesis Frizzled Binding Regulation Of Cell Morphogenesis Wnt Signaling Pathway Cytochrome C Metabolic Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cytoplasmic Microtubule Organization Tube Morphogenesis Mitotic Cleavage Furrow Formation Morphogenesis Of An Epithelium Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Ganglioside Galactosyltransferase Activity Clathrin-coated Vesicle Calcium Oxalate Binding Aortic Valve Formation Protein Kinase Binding Positive Regulation Of Vascular Associated Smooth Muscle Contraction Tissue Morphogenesis Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration Regulation Of Cytokinesis Positive Regulation Of Protein Localization To Presynapse Canonical Wnt Signaling Pathway Negative Regulation Of Stress Granule Assembly Collagen Fibril Binding IgA Binding Beta Selection Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Cytochrome Metabolic Process Bone Trabecula Morphogenesis Regulation Of JNK Cascade Dendritic Spine Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Matrix Side Of Mitochondrial Inner Membrane Organelle Organization Regulation Of Cell Division Regulation Of Systemic Arterial Blood Pressure By Endothelin	Blood Microparticle Regulation Of Growth Acute-phase Response Platelet Alpha Granule Lumen Acute Inflammatory Response Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Insulin Receptor Signaling Pathway 1-phosphatidylinositol-3-kinase Activity Positive Regulation Of ATP Biosynthetic Process Endothelial Cell Migration Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of ATP Biosynthetic Process Negative Regulation Of Anoikis Actin Cytoskeleton Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Cellular Response To Hypoxia Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Binding Regulation Of Cell Growth Regulation Of Anoikis Actin Filament-based Process Positive Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of ATP Metabolic Process Biological Process Involved In Interaction With Symbiont Endodermal Cell Differentiation Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cytokine Production Involved In Inflammatory Response Phosphotyrosine Residue Binding Phosphatidylinositol Phosphate Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Positive Regulation Of Growth Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Defense Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Activation Platelet Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Complement Activation, Lectin Pathway Enterobactin Binding Exogenous Protein Binding Endoplasmic Reticulum Lumen