DUSP4 and GRIN2D

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		DUSP4	GRIN2D
Gene Name		dual specificity phosphatase 4	glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Plasma Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Postsynaptic Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding
	Biological Process	MAPK Cascade Inactivation Of MAPK Activity Endoderm Formation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Dephosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Peptidyl-tyrosine Dephosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade	Startle Response Signal Transduction Synaptic Transmission Adult Locomotory Behavior Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Sensory Perception Of Pain
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Orphenadrine Tenocyclidine
Diseases
GWAS		Response to statin therapy ( 20339536)
Protein-Protein Interactions		9 interactors: APP CRMP1 GRIN1 GRIN2D MAPK1 MAPK14 MAPK3 MAPK8 MAPK9	33 interactors: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA INADL MAP2 MAP2K2 NANOS1 NF1 PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		1846	2906
HPRD ID		04123	04095
Ensembl ID		ENSG00000120875	ENSG00000105464
Uniprot IDs		Q13115	O15399 Q59G17
PDB IDs		3EZZ
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To External Stimulus Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Response To Abiotic Stimulus Chemotaxis Signal Transduction By Phosphorylation Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Gene Expression Cellular Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Response To Radiation Neuron Development Immune Response-regulating Signaling Pathway Apoptotic Process Response To Bacterium Programmed Cell Death Ionotropic Glutamate Receptor Signaling Pathway Platelet Activation Cell Death Death Cell Morphogenesis Axonogenesis Regulation Of Golgi Inheritance JUN Phosphorylation Neurotrophin TRK Receptor Signaling Pathway	Nervous System Development Regulation Of MAPK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurogenesis Cell Development Locomotion Generation Of Neurons Intracellular Signal Transduction Neuron Projection Development Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Neuronal Synaptic Plasticity Cellular Response To Stimulus Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Cell Projection Organization Signaling Cell Morphogenesis Involved In Differentiation Axonogenesis MyD88-independent Toll-like Receptor Signaling Pathway Neuron Development Cell Communication Apoptotic Process Response To Organic Substance Signal Transduction Axon Guidance Axon Development Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cell Death Toll-like Receptor 4 Signaling Pathway Death Regulation Of Neuron Death Developmental Process Neuron Projection Morphogenesis Response To Ammonium Ion Immune Response-regulating Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Response To Morphine Regulation Of Intracellular Signal Transduction Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development Response To External Stimulus Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process
Tagcloud ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?