DUSP4 and CRMP1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DUSP4	CRMP1
Gene Name		dual specificity phosphatase 4	collapsin response mediator protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Microtubule Organizing Center Spindle Cytosol Dendrite Neuronal Cell Body
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides
	Biological Process	MAPK Cascade Inactivation Of MAPK Activity Endoderm Formation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Dephosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Peptidyl-tyrosine Dephosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)	Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		9 interactors: APP CRMP1 GRIN1 GRIN2D MAPK1 MAPK14 MAPK3 MAPK8 MAPK9	78 interactors: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LSM2 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1D1 ZAK ZNF24
Entrez ID		1846	1400
HPRD ID		04123	03913
Ensembl ID		ENSG00000120875	ENSG00000072832
Uniprot IDs		Q13115	B3KT07 E9PD68 Q14194 Q96I11
PDB IDs		3EZZ	4B3Z
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To External Stimulus Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Response To Abiotic Stimulus Chemotaxis Signal Transduction By Phosphorylation Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Gene Expression Cellular Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Response To Radiation Neuron Development Immune Response-regulating Signaling Pathway Apoptotic Process Response To Bacterium Programmed Cell Death Ionotropic Glutamate Receptor Signaling Pathway Platelet Activation Cell Death Death Cell Morphogenesis Axonogenesis Regulation Of Golgi Inheritance JUN Phosphorylation Neurotrophin TRK Receptor Signaling Pathway	Cell Death Death Developmental Process Apoptotic Process Programmed Cell Death Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Catabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cysteine-type Endopeptidase Activity Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Organic Substance Protein Homooligomerization Response To Stress Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Cytoskeleton Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Cellular Process Stress-activated MAPK Cascade Nervous System Development Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity System Development Positive Regulation Of Catalytic Activity Postreplication Repair Regulation Of Cellular Component Organization Protein Oligomerization Cellular Macromolecule Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Complex Assembly Heterocycle Metabolic Process
Tagcloud ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa	aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?