DUSP4

Gene Name		dual specificity phosphatase 4
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	MAPK Cascade Inactivation Of MAPK Activity Endoderm Formation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Dephosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Peptidyl-tyrosine Dephosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade ERKs are inactivated Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)
Protein-protein Interactions		9 interactors: APP CRMP1 GRIN1 GRIN2D MAPK1 MAPK14 MAPK3 MAPK8 MAPK9
Entrez ID		1846
HPRD ID		04123
Ensembl ID		ENSG00000120875
Uniprot IDs		Q13115
PDB IDs		3EZZ
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To External Stimulus Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response MAPK Cascade Regulation Of Innate Immune Response Response To Abiotic Stimulus Chemotaxis Signal Transduction By Phosphorylation Response To Lipopolysaccharide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Gene Expression Cellular Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Response To Radiation Neuron Development Immune Response-regulating Signaling Pathway Apoptotic Process Response To Bacterium Programmed Cell Death Ionotropic Glutamate Receptor Signaling Pathway Platelet Activation Cell Death Death Cell Morphogenesis Axonogenesis Regulation Of Golgi Inheritance JUN Phosphorylation Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		amphiregulin areg betacellulin btc calgb cd73 cetuximab chemo epgn epigen epiregulin erbb3 erbb4 ereg folfiri folfox formalin hbegf her3 her4 implicate kras mcrc modeled multiplicative nt5e pfs phlda1 tgfa